ID A0A4W6CCP5_LATCA Unreviewed; 1038 AA.
AC A0A4W6CCP5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSLCAP00010009025.1};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSLCAP00010009025.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010009025.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010009025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 chloride(out) + K(+)(out) + Na(+)(out) = 2 chloride(in) +
CC K(+)(in) + Na(+)(in); Xref=Rhea:RHEA:72395, ChEBI:CHEBI:17996,
CC ChEBI:CHEBI:29101, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72396;
CC Evidence={ECO:0000256|ARBA:ARBA00034631};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A4W6CCP5; -.
DR Ensembl; ENSLCAT00010009232.1; ENSLCAP00010009025.1; ENSLCAG00010003607.1.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 127..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..96
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 126..631
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 640..1038
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 114603 MW; 0531FD21CBFF829D CRC64;
MERFKSNGGE HVNSAYDSTL DEPPIYETTF SNGEHRTVRP SVVSAFGHDT LDRVPNIDFY
RNAGSVSGHR AVRPSLQELH DVFQKVNLND SLDDVEGSDG TPSDDLESAV PIDSKKGAVK
FGWIRGVLVR CMLNIWGVML FIRLSWVFGQ AGWGLGIVVI ALSCVVTTIT GLSMSAICTN
GVVRGGGAYY LISRSLGPEF GGSIGLIFAF ANAVAVAMYV VGFAETVVEL LKDHSALMVD
EINDIRIIGC ITVVLLLGIS VAGMEWEAKA QIVLLIILLV AIVNVFVGTF IPATEDKKSK
GFFNYNSKIF LENFMPDFRE KETFFSVFAI FFPAATGILA GANISGDLRD PQAAIPKGTL
LAIVITGITY LAVALCVSAT VVRDATGNIT NAIVPGGFCN GSTAVACELG YDFSSCEVEK
CKFGLMNNFQ VMTMVSGFGP LIIAGTFSAT LSSALASLVS APKVFQALCK DNIYKALYFF
AKGHGKNNEP IRGYILTFII SVAFILIGNL NTIAPIISNF FLASYALINF SCFHASYAKS
PGWRPAYKYY NMWLSLVGAV LCCAVMFVIN WWAALLTYGI EILLYIYVTV KKPDVNWGSS
TQAVTFVSAV SNALSLSGVD DHVKNFRPQI LALTGSARTR PALLDLAHSF SKNYGLCLTC
EVFVGPRSEA LQEMNAGMEK NQQWLRKTKR KAFYAAVACD SFREGTESLL QASGLGRMRP
NTLMMGFKRN WRTAGTESVQ NYVGILHDAF DFEYGTVILR MNQGLDVSHI VEAEEEMLKA
AKEQQALEKE MMPNGGKSRG LFRKSRKSSQ QVLTTRVSVC GPPPPQVAKM NERLLEASSQ
FKKKQPKGTI DVWWLFDDGG LTLLLPYILT TRKKWKDSNL RIFIAGQPER SELDKQEMKS
LLQKFRINCT DITVIDDIHL RPSSDSLRNL EDMIEPFRLH EGSKDTAQAE AMQKEQPWKI
TDKELSEFEE KTNLQLRLNE VLQQNSKSAN LIIVSMPIAR KESISDFLYM AWLDVLTKDL
PPTLLIRGNH KSVLTFYS
//
