ID A0A4W6D0M6_LATCA Unreviewed; 899 AA.
AC A0A4W6D0M6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 2 {ECO:0000313|Ensembl:ENSLCAP00010018378.1};
GN Name=LOC108891467 {ECO:0000313|Ensembl:ENSLCAP00010018378.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010018378.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010018378.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A4W6D0M6; -.
DR Ensembl; ENSLCAT00010018781.1; ENSLCAP00010018378.1; ENSLCAG00010008549.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF3; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 5.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..899
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021321372"
FT DOMAIN 28..68
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 111..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 276..316
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 317..355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..823
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 321..331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 899 AA; 100106 MW; 31446C34B2ABCD8B CRC64;
MGAIWAARDF CLFLLLLNSR QSAALPEIRD PCADGSDGCH IDAICQTTQG SYKCTCKAGF
KGDGKHCEDT DECDLEHNGG CVHECNNIPG NYRCTCYDGF NLAHDGHNCL DVDECKFNNG
GCQHTCVNTM GSYECRCKDG FFLSDNQHTC IHRSVEGLNC MNKEHGCAHI CRETPRGGVA
CECRPGFELA RNQRGCILTC NHGNGGCQHT CEDTENGPIC RCHVRYTLQP DKRSCVETCA
VNNGGCDCTC KDTSTGVRCS CPVGFTLQPD GKTCKDIDEC ELHNGGCDHF CRNTIGSFEC
NCRKGFKLLT DERSCQDIDE CFFERTCDHT CVNSPGGFQC LCNKGYTMYG LAHCGDINEC
SVNNGGCEQG CENTMGGFEC FCHPGYKLHW NKKDCIGKLV PPPIRQARLS SAVAEIIRFL
FTENVQFSYV SLRCTSSGQR PRSRHGRKAG EEDGSSITAE FELDVNVEEV TAESCDLNCV
RRRSEKRLRK TIRTLRKSIN REQFHLHFAG SDYELSRNPD QPAELAGHCA GGQVLMGRKC
VSCSVGTYYD GDQGRCLLCP AGTYQDEEGQ MSCEVCPGPE GREVSKVVGA RNMSECGGQC
SPGHYSHDGF LPCLPCPLGT YQPEVGRTTC FACGGNLVTK RSGAVTFQEC ETKVQCSPGH
YYNTSTHRCI RCPMGTYQGE FGQNYCVSCP GNTTTDFDGS TNIMQCKNRQ CGGELGDFTG
YIESPNYPGN YPANIECTWT INPPPKRRIL IVVPEIFLPI EDECGDYLVM RKSSLSNSVT
TYETCQTYER PIAFTSRSKR LWIQFRSNEG NSGKGFQVPY VTYDEDYQEL IEDIVRDGRL
YASENHQEIL KDKKLMKALF DVLAHPQNFF NYTAQESREM FPKSFIRFLR SKVLRFLRP
//
