ID A0A4W6D5Y8_LATCA Unreviewed; 1282 AA.
AC A0A4W6D5Y8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=FERM domain-containing protein {ECO:0000259|PROSITE:PS50057};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010020197.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010020197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSLCAT00010020647.1; ENSLCAP00010020197.1; ENSLCAG00010009543.1.
DR GeneTree; ENSGT00940000158442; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF20; BAND 4.1-LIKE PROTEIN 3; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980}.
FT DOMAIN 52..333
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1102..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..441
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1282 AA; 144648 MW; 4D06C6231EA3725F CRC64;
MQDSASDSKM AKQEQNSKHL DEHRETDEMS EKTSPNKNLK SPQKGSKRLK TIPFKVTLLD
SSEFEGEIEK HSKGQTLMDM VCEHLNLLEK DYFGLTFADT DTQKNWLDPS KEIKKQMRNS
PWHVAFAVKF YPPDPSQLTE DITRYYLCLQ LRDDMLSGRL PCSFVTHALL GSYTVQAELG
DYDQDDHGSD YVSDFRFAPN QTRELEERVM ELHRNYKGMT PAEAEMNFLE NAKKLSMYGV
DLHHAKDSEG IDIMLGVCAN GLLIYRDRLR INRFAWPKIL KISYKRSNFY IKIRPGEYEQ
FESTIGFKLP NHRAAKRLWK VCIEHHTFFR LVSPEPPPKG FLVMGSKFRY SGRTQAQTRQ
ASALIDRPAP HFERSTSKRY LLSRSLDGEF SRPVSAMCEN HDGLSHRSIS EQRRLHSPSV
DEQETELEPS LEQDEEDKDQ ERDLSEQDKN DDGNITPNRK KEIMFLDKSQ DVLLKHQASI
NELKRALREP NSKLMNREKR LSATSPTGTP EKKAGSEEWV LIEKQQPYQR DHDWKAEEKN
KSFTSDSSWE TKELEKEIDV TKMIHKEVTG YDRKEMKSHT DEFPSTKSSS EADVRPESWP
TNKSPFVIEL SENADPFRDK SQSKPSQASD PEANSDVALG LRQIKERTAS KQRKKRRPQS
LNLGMPAELI YRKGGSDSTG EENEGSNSDI SPEKTFQTGN HYESSKVVVK KGDQGSGKDQ
SVKDSKQEEI SIGENREVST QGTEQVKRKV SQVGTTDIDL GSVNGPGKIE HDSSLAGVKG
ECTMKVRGKS LIDNKELAEV KLRQVRTHEQ KISSSAAEDI EGFMGERGQR TSFHRLSSSG
YQSEITRIVP LKPERSKSVV CKDERDRTGQ DEPTRVIRRE YRWSVGSPEG SSDLNWTDVS
TFHSAFAADL EVVAKTEQPD NSYQFGRGPT ESQSFGSKIS ALPKMAPPAP PVKTQKARES
GLILRNSRNA GREPSLDAAK KRHSEPVSTP AIYEEPFADF KEGLGDRKPQ PSVAPEEEQE
RDTVTCMRET HLGIERKCSS MTVSSTSSLE AEVDFTIITD LHSGVEDFSK GLLDLGERER
QPEVGREDFE ETSRFYSARL MGSRDKSPIE EKLPEGTHHE PPVAKKDPTA VSMAHMLRRA
DTKTQTHTNG SEVHPHIMNV SPQNYGAVSP QEAPAALKEN GSPVKASTQG RESVVSPLTI
TAESVTSATT TQVTKTVKGG YSETRIEKRI IITGDDDVDQ HQALAMAIQE AKQQHPDMLV
TKAVVIRETD SPTEELQQKS ES
//
