ID   A0A4W6D713_LATCA        Unreviewed;      1265 AA.
AC   A0A4W6D713;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
GN   Name=LOC108897341 {ECO:0000313|Ensembl:ENSLCAP00010020618.1};
OS   Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX   NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010020618.1, ECO:0000313|Proteomes:UP000314980};
RN   [1] {ECO:0000313|Proteomes:UP000314980}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Sai Rama Sridatta P.;
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLCAP00010020618.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC       subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR   AlphaFoldDB; A0A4W6D713; -.
DR   STRING; 8187.ENSLCAP00010020618; -.
DR   Ensembl; ENSLCAT00010021074.1; ENSLCAP00010020618.1; ENSLCAG00010008896.1.
DR   GeneTree; ENSGT01030000234563; -.
DR   InParanoid; A0A4W6D713; -.
DR   Proteomes; UP000314980; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.10.70.80; -; 1.
DR   Gene3D; 3.30.60.270; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF8; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS1; 1.
DR   Pfam; PF00801; PKD; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 1.
DR   Pfam; PF15901; Sortilin_C; 1.
DR   SMART; SM00602; VPS10; 1.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR   SUPFAM; SSF49299; PKD domain; 2.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..1265
FT                   /note="PKD domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5021219480"
FT   TRANSMEM        1145..1165
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          866..922
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
FT   REGION          73..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        93..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1265 AA;  141328 MW;  473A0C6440DB1184 CRC64;
     METRLGHCLF VIFSEWIWLF SLTSSLGGTK GAEVRCIPPC RLSLITAFPR ELSALDLTNS
     GETPAEEFVG FFEGSPGAEP TAGGEEKPNV AEFTASEETS SKVQPRLRGN KTSCLQEDAS
     NGQQKLSHSK EFPAPLPTNV RENGTGDAKN NSFYGGNGAQ VDVTVNEDED VASWRRARRS
     AETWSRFRPE GGDEASFSDQ EEFQLISSTF ALSGDTAHNQ AMVHWSGQNS SVILMLTKYY
     DFNTGRVTES SLWRSTDYGT TYEKLNEKVG PKTILSYLYV SPNNKRKIML LTDPEVESSL
     LISLDEGASY QKHSLSFDIL SLLFHPEQED WILAYSHDQK LYVSVEFGRR WQLVHDGVVP
     NRFYWSRLGL DKEQGMIHLE ISVSDGRSQY ITCKLQNCSD GNKGKPFPGF IIPNSLVVQD
     EYVFIQVPIG GQSVHYVSYK RNSFYPMKLP KYTLPKDLQI ISTDDNQVVA AIQDWHQNDS
     YNLYMSESRG LFFTLMLENV VSSKGPEGNI MIDLYEVAGI KGVFLSNKVV ENQVKTYITY
     NKGRDWHLLQ APTTDLQGNK VYCEQPFCSL HLHLHVSENP YTSGNIVSKD SAPGIIIASG
     VVGPELTTTN VSIFITSDAG NTWREVFQEE YSVFFLNQGG SLVAIRHTPL PIRHIWLSFD
     EGRNWDKYSF TSSPLYVDGV LGEPGEDTLI MTIFGHFSHR SEWQLVKIDF RSVFQHRCTS
     EDYLTWQLHS EGEVCIMGMK RIFQKLKANV RCVKARDQYI SQMSDSCPCT DADFECDYGF
     ERQVDGSCTP AFWFIPSATS RDCITGESFL NTTGYRKALS NNCTDGVLLK YSPRRQKCPS
     QAPRGLQLFT SEGTLVATVG RNVTFLVFLE EGLGSTTSIT VDFGDGTAIS YVNISSIDDG
     VKHMYSKVGI YQVSATASNS LGFDRVILYL HVSCQLEQVL LSAPSVVVKN KAVNLTTVLR
     PSNVGTVIYY WWFDNKTEPV VTLDGAMSFT FPKEGSHRVT VQASAGNTVH QDQMTVAVYD
     YFRSHVLAFS SNLDELNPGV SEWREDISRV VKSSMVQVTG IGEDQLLVTV LPGLPTTAEI
     FIVPEKRSRD GATDEKWLSQ VLLSALNQDL IQFTLKPGVQ VNVYATRLSP APLVDSSDSG
     HSGTAVIMLV SVVLMGLAIF VIYKFKRYSI LDTMNLFRLH ISLSYGHPQH NNSLRNKTIP
     LCLNLQNITG NDSLINSPKV LNGCQSPAVI NIHLSDNVRV DLLEMLNTAI QGEAYSAKWQ
     ERLRR
//