ID A0A4W6DDF4_LATCA Unreviewed; 999 AA.
AC A0A4W6DDF4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 3 {ECO:0000313|Ensembl:ENSLCAP00010022889.1};
GN Name=LOC108882096 {ECO:0000313|Ensembl:ENSLCAP00010022889.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010022889.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010022889.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_018529895.1; XM_018674379.1.
DR AlphaFoldDB; A0A4W6DDF4; -.
DR Ensembl; ENSLCAT00010023386.1; ENSLCAP00010022889.1; ENSLCAG00010010627.1.
DR GeneID; 108882096; -.
DR CTD; 222663; -.
DR GeneTree; ENSGT00940000153185; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..999
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021465611"
FT DOMAIN 34..74
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 289..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..368
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 809..921
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 334..344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 999 AA; 110245 MW; 1666640FD0E137AD CRC64;
MYMHALIRAS LGFVGFCLVV FVQQSASGSK TTQDVDECAE ALDNCSIDAI CQNTLKSYKC
ICKSGYKGDG KHCEDVDECA TEYNGGCVHE CINIPGNYRC TCYDGFRLAH DGHNCLDVDE
CSEGNGGCQQ ICVNMMGSYE CRCREGFLLS DNQHTCIQRP KVQPEGAKEG PTCMDKNHGC
AHICRETQKG GISCECRPGF QLTRNMKDCK LTCNYGNGGC QHICEETDHG PKCSCHMKFV
LHSDGKTCVE TCAVNNGGCD STCHDSVTGV RCSCPVGFTL QPDRKTCKDI DECRLNNGGC
DHVCRNTVGS FECSCKKGYK LLTNERTCQD IDECSFDRAC DHFCVNSAGS FQCLCHKGYV
LYGLAHCGDI DECSINRGGC KYGCINTLGS YECTCPPGYK LHWNRKDCIE LVKCPPGLVA
PKATLTCSKT GKKESCSLTC ASKAHYLAES DNSYSVSCGI PILRGKSPTR LNSSSSQSCI
ETLAPPVKQT ASFKIKNAKC HLHPKLTGRT EDRGRTLGPG GGQPCSNCLV TFVNLKCDSS
KKTKGRRARN PANKEVTRIT LELEAEVKPG DTTGSCNLSC LRQRMEKQVK TYIKALKKSI
NQERFLIRVA GLEYEVAQKL PQAAPVQENC GPGWERDSGR CVRCLSGSYY HGEQERCVQC
PPGTFQEKEG QLACDLCPGS DGHGPVGARN ISSCAGQCPT GSFSSDGFKP CQPCPQGTYQ
PDLGRTLCFP CGGGLSTKRE GASSFHDCEV KVQCSPGHYY NTSVHRCIRC PVGTYQTEFR
QNYCISCPGN TTTDFDGATS VSQCKNRQCG GEMGEFMGYI ESPNYPGNYP ANVECIWNIN
PPSKRKILIV VPEIFLPSED ECGDVLVMRK NWSATSITTY ETCQTYERPI AFTARSRRLW
INFKSNEANS ARGFQIPYVT YDEDYEQLVE DIVRDGRLYA SENHQEILKD KKLIKTLFDV
LAHPNNYFKY TTRESNEMLP RSFIRLISSK VSAFLRPYK
//
