ID A0A4W6E0V4_LATCA Unreviewed; 623 AA.
AC A0A4W6E0V4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010031034.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010031034.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip.
CC {ECO:0000256|RuleBase:RU367070}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR AlphaFoldDB; A0A4W6E0V4; -.
DR Ensembl; ENSLCAT00010031729.1; ENSLCAP00010031034.1; ENSLCAG00010014579.1.
DR GeneTree; ENSGT00390000010116; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367070};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW ECO:0000256|RuleBase:RU367070}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW ECO:0000256|RuleBase:RU367070}.
FT REPEAT 40..73
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT COILED 360..394
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 623 AA; 71898 MW; 659495DF2AABE41E CRC64;
MTAIKDGEYT ATIYKLIKDG QYVEAIHILN GQLQKHTKSR AALSLLGYCY YHIQDFTNAA
ECYEQLTQLH PEVEEYKVYY AQSLYKAGAY PEATKASFVL DNPSSHTKMV KLQACIKYCE
EDYSAAKSLL EQLPQDDPDY VYNMGCLLYQ DGKHEDACKK FMSAMQVLGY VPALSYNIAL
CYYSLKNYAQ ALKYIGEIIE RGIREHPELS VGMTTEGIDV HSVGNTLVLH QTALIEAFNL
KAAIEYQLKN LKGAQEALTD MPPRSEEELD PVTLHNQALL NMDTKPSEGF EKLAFLLQQP
SFPPVTFGNL LLLYCKHEYF DLAADVLAEN AHLTYKFLSP YMYEFLDALL TCQTAPEEAF
RKFDEMNAKL TEQLRKLAKQ VQEARLARDD EAQKKALQDY DLMQEKYIVV LMAQAKIYWN
RENFQMVEKI FRKSVEVCNE DDTWKLNVAH VLFMQNKYKE AIGFYEPIVK KHYDNILNVS
AVVLANLCVS YIMTSQNEEA EELMRKIEKE EEQISYDDPD KKVFHLCIVN LVIGTLYCAK
GNYDFGISRV IKSLEPYNKK VSHFMCCWVF TESLPPLPQQ SRYSQCIFVF IFQRQQEIFS
LFHRLSDGEE VINTRTRIIL ALK
//
