ID A0A4W6EIB9_LATCA Unreviewed; 1067 AA.
AC A0A4W6EIB9;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Solute carrier family 12 member 5b {ECO:0008006|Google:ProtNLM};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010038799.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010038799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A4W6EIB9; -.
DR Ensembl; ENSLCAT00010039716.1; ENSLCAP00010038799.1; ENSLCAG00010016285.1.
DR GeneTree; ENSGT00940000165387; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..235
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 351..635
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 649..765
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 781..911
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1000..1067
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 28..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 117437 MW; 0893A6BF668672AF CRC64;
VCILQEEMDT SPMVSSLLST LANYSNLPTG SKEHEEAENN EEGARPSKKP VKAPQLGTLM
GVYLPCIQNI FGVILFLRMT WMVGIGGVFG SFIIVFMCCS TTMLTAISMS AIATNGVVPA
GGSYYMISRS LGPEFGGAVG ICFYLGTTFA GAMYILGCIE ILLIYIVPQA AIFKIEGLEG
PEAEAALLNN MRVYGTIVLS FMALVVFVGV KYVNKLALVF LACVILSILA VYAGVIKTAI
DPPVFPVCLL GNRTLLSKAY DVCAKVVEID NETVTTKLWR SFCDSDSLNA TCDEYFMNNN
VTEIQGIPGV TSGILAENLF GNYLEKGMML EKRGLASDTD PDSPVTSSNR YVLADITSFF
TLLVGIYFPS VTGIMAGSNR SGDLRDAQKS IPIGTIAAIT TTSTVYMSCV VLFGACIEGV
VLRDKFGEGV NGNLVIGTLA WPSPWVIVFG SFFSTCGAGL QSLTGAPRLL QAISRDGIIP
FLRVFGHGKA NGEPTWALLL TAGICEIGII IASLDSVAPI LSMFFLMCYM FVNLACALQT
LLRTPNWRPR FKFYHWALSF LGMSLCLSLM FICSWYYAIV AMGIATCIYK YIEFCGAEKE
WGDGIRGISL SAARFALMRL EEGPPHTKNW RPQILVLVSV DGEQNVEQPR LLSLTNQLKA
GKGLTIVGTA VQGTFLDNYT EAQKADQSLR KLMETEKVKG FSQVVISSNL RDGTSHLIQV
GGLGGLKHNT VMVSWPRNWK QPECHQQFRN FIEVVRETTV ASLALLVPKN ISSYPSNGER
FTEGHIDVWW IVHDGGMLML LPFLLRQHKV WRKCKMRIFT VAQMDDNSIQ MKKDLITFLY
HLRIDAEVEV VEMHDSDISA YTYEKTLVME QRSQILKQMH LTKNEMEREI QSITDSSRGS
IRRKNPPNLR SQHSAEEGTS VAEKPEEESM AVSNPKQVQL IHSKNTSTPT SPTSPMSPAA
PAGGAATWTD NKGPDKGKTL LAEPNKDLFN MKPNQTDVRR MHTALRLNEV IIKKSKEAKL
VLLNMPGPPR NRVGIENYME FLEVLTEGLN RVLLVRGGGR EVITIYS
//
