ID A0A4W6ERE5_LATCA Unreviewed; 972 AA.
AC A0A4W6ERE5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Signal peptide, CUB domain, EGF-like 1 {ECO:0000313|Ensembl:ENSLCAP00010040857.1};
GN Name=LOC108897507 {ECO:0000313|Ensembl:ENSLCAP00010040857.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010040857.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010040857.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A4W6ERE5; -.
DR Ensembl; ENSLCAT00010041856.1; ENSLCAP00010040857.1; ENSLCAG00010019109.1.
DR GeneTree; ENSGT00940000153185; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 3.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..52
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 261..301
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 302..340
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 782..894
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 473..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 306..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 972 AA; 107468 MW; C863F9B86DB6AE08 CRC64;
MRFSFHGQLQ AYADECAEGS DDCHIDALCQ NTPKSYNCIC KPGYKGDGKQ CEDMDECEND
YNGGCVHECI NIPGNYRCTC YDGFMLAHDG HNCLDVDECL DNNGGCQQVC VNTMGSYECL
CTEGFFLSDN QHTCIHRSDD GMNCMNKDHG CAHICREAPG KGGVSCECRP GFELAKNQKD
CTLTCNYGNG GCQHTCDDTD TGPVCGCHQK YALHSDSKTC IETCAVNNGG CDRTCKDTAT
GVRCSCPVGF TLQPDGKTCK DIDECQENNG GCDHFCRNTV GSFECSCQKG HKLLTDERTC
QDIDECSFER TCDHTCINYP GSFECLCNKG FILYGLTHCG DIDECSINNG SCEYGCINTQ
GSYECVCPPG QKLHWNKKDC IEAVKCLPNG KPAPRAQLTC TKSGGAEVCS LSCPSNALFL
ADSENSYTLS CGVPVQPGKA PQKRNATTAL PTCADMLAPP IKQKARFKIK DAKCHLRPRN
KEKHRDSSKQ NLQGGQFPCT DDCQVTFVNL KCDSSKKRRR GRKSPSKEVS HITAEFEMEM
KEEEASDSCN VDCVRERMKQ KLQSAMRTLR KSINKQQFYI QFSGTEYEVA QKPSRVPEGA
ETCSTGQVLR EGKCVSCGVG TYYSGEQEQC VQCPPGTYQD TVGQLSCEPC PSTEGQGVAG
AKNVSQCGGQ CPAGHFSADG FRPCQPCALG SYQPEPGRVL CFPCGGGLMT KYEGSVSFRD
CEAKVHCAPG HYYNSSTHRC IRCPAGTYQS EFGQNYCITC PGNTTTDFDG ATNVSHCKNQ
LCGGELGEYT GYIESPNYPG DYPSNVDCVW TINPPHKRRI LIVVPEIFLP IEDECGDVLV
MRKSAVPTSI TTYETCQTYE RPIAFTSRSR KLWIQFKSNE GNSGKGFQVP YVTYDEDYQQ
LIEDIVRDGR LYASENHQEI LKDKKLIKAL FDVLAHPQNY FKYTAQESKE MFPRSFIKLL
RSKVTRFLRP YK
//
