ID A0A4W6F2T7_LATCA Unreviewed; 848 AA.
AC A0A4W6F2T7;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Premelanosome protein a {ECO:0000313|Ensembl:ENSLCAP00010044394.1};
GN Name=LOC108898947 {ECO:0000313|Ensembl:ENSLCAP00010044394.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010044394.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010044394.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR AlphaFoldDB; A0A4W6F2T7; -.
DR STRING; 8187.ENSLCAP00010044394; -.
DR Ensembl; ENSLCAT00010045497.1; ENSLCAP00010044394.1; ENSLCAG00010020647.1.
DR GeneTree; ENSGT00950000183188; -.
DR InParanoid; A0A4W6F2T7; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..848
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021280002"
FT TRANSMEM 774..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 244..275
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 378..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 86951 MW; 9E3EBEB86C1AC320 CRC64;
MRTLALVLLV LAFTSASAIK PRSQFTQYRS WNSRMYPVWR DGDPRFRNCW SGGEVTFDLK
NDAPTLTGAR ATFNINLNFP PNQTVLPDGQ VVWARNCTVD GQEYQEGQAV YPDQGTEQMG
LFPDGTPFTR SQNKKPRYVF VWKTWGRYWQ VADGPSSSLT IGTDNVPLGS YSMEVVIYHC
RGRNRFIPLG YASSVFTITD QVPFTISLAQ VNDVNQDDQN FIQNRAIAFS VNLHDPSQYL
NSADISFSWD FGDSTGTLIS RERTVTHTYL AVGTFKPQVV LMASIPNGCG NPTAVVPIDA
SAAPAVVVMP STSAAVPAVP AEGGDAIALD VPASVQPDDA ATNAEDGEAV VNTGTDVVEV
ASVAPAGVDA AVVPEEQDPA NAAAEGDAAA EETDAAAGEV VPAAEEAVDA DIAAAADETA
VVADAAAEDV PVIDAAAASV APVAEGEEAV EQEVDGDAAA ADAAAATDAD AAADAAADAA
TIDVAAEAAA ADPAEADAAA ADAAIDAAAD AAAADAATVD AAAAADAAAA DAADDAAAVA
AADAAAADAA AEVVQAETEA PAENVVAPAA TEATAVEEAA LVEAAADTEA EVLETENEVA
ATAAAAEQPA GEEEAAPAEG EVQVEVETDP AQVALVVAKR QAPELTADCM VYRYGSLATS
LDVVQGIESV EIVQVSNVVS MATELDQNAV DVTISCQGSL PSEVCTVISD ADCITPVETV
CNAASPSPDC QMILRQFFND SGVFCINVSL TNDVSLAVAS ARVSVTVASG GSPAGTAATV
LGVMVLACVV CCIGLMYRRF KQYQPLREDH GVSNGGSSGV TSVPLLLWNL LSRQSPGESR
PLLQGRIV
//
