ID A0A4W6F592_LATCA Unreviewed; 424 AA.
AC A0A4W6F592;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Flotillin {ECO:0000256|RuleBase:RU366054};
GN Name=FLOT1 {ECO:0000313|Ensembl:ENSLCAP00010045071.1};
OS Lates calcarifer (Barramundi) (Holocentrus calcarifer).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Carangaria; Carangaria incertae sedis; Centropomidae; Lates.
OX NCBI_TaxID=8187 {ECO:0000313|Ensembl:ENSLCAP00010045071.1, ECO:0000313|Proteomes:UP000314980};
RN [1] {ECO:0000313|Proteomes:UP000314980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sai Rama Sridatta P.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLCAP00010045071.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May act as a scaffolding protein within caveolar membranes,
CC functionally participating in formation of caveolae or caveolae-like
CC vesicles. {ECO:0000256|ARBA:ARBA00025336}.
CC -!- SUBUNIT: Heterooligomeric complex. {ECO:0000256|RuleBase:RU366054}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Melanosome
CC {ECO:0000256|ARBA:ARBA00004223}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane, caveola
CC {ECO:0000256|ARBA:ARBA00004543}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004543}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170, ECO:0000256|RuleBase:RU366054};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}. Endosome
CC {ECO:0000256|RuleBase:RU366054}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. Flotillin subfamily.
CC {ECO:0000256|ARBA:ARBA00007161, ECO:0000256|RuleBase:RU366054}.
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DR RefSeq; XP_018529634.1; XM_018674118.1.
DR AlphaFoldDB; A0A4W6F592; -.
DR Ensembl; ENSLCAT00010046177.1; ENSLCAP00010045071.1; ENSLCAG00010020922.1.
DR GeneID; 108881911; -.
DR KEGG; lcf:108881911; -.
DR CTD; 561345; -.
DR GeneTree; ENSGT00560000077232; -.
DR OrthoDB; 5486670at2759; -.
DR Proteomes; UP000314980; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03399; SPFH_flotillin; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR031905; Flotillin_C.
DR InterPro; IPR027705; Flotillin_fam.
DR PANTHER; PTHR13806:SF47; FLOTILLIN-1; 1.
DR PANTHER; PTHR13806; FLOTILLIN-RELATED; 1.
DR Pfam; PF01145; Band_7; 1.
DR Pfam; PF15975; Flot; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366054};
KW Reference proteome {ECO:0000313|Proteomes:UP000314980}.
FT DOMAIN 84..266
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
SQ SEQUENCE 424 AA; 47454 MW; 43CB4A0265A70B21 CRC64;
MFYTCGPNEA MVVSGFCRSP PMMIAGGRVF VIPCVQQLQR ISLNTLTLNV KSDKVYTRHG
VPISVTGIAQ VKIQGQNKQM LAAACQMFMG KSEPEIAQIA LETLEGHQRA IIAHLTVEEI
YKDRKKFSEQ VFKVASSDLV NMGISVVSYT LKDVHDDQDY LQSLGKARTA QVQKDARIGE
AQNKRDAVIR EAHAMQEKVS AQYKNEIDMA KAQRDYELKK AAYDIEVNTK KAESEMAYQL
QVAKTKQRIE EEKMQVQVVE RTQQITLQEQ EITRREKELE AKVKKPAEAE RYRLEKLAEA
QRLKLIMEAE AEAESIRIKG EAEAFAVEAR GRAEAEQMSK KAEAFQQYKD GAMVDMLLEK
LPLMAEEISK PLCEAKKVTM VSSGNGEVGA AKLSGEVLDI MTRLPETVEK LTGVNISQVS
SRTG
//