ID A0A4X2JRM6_VOMUR Unreviewed; 445 AA.
AC A0A4X2JRM6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Fas associated factor family member 2 {ECO:0000313|Ensembl:ENSVURP00010002198.1};
GN Name=FAF2 {ECO:0000313|Ensembl:ENSVURP00010002198.1};
OS Vombatus ursinus (Common wombat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Diprotodontia; Vombatidae; Vombatus.
OX NCBI_TaxID=29139 {ECO:0000313|Ensembl:ENSVURP00010002198.1, ECO:0000313|Proteomes:UP000314987};
RN [1] {ECO:0000313|Proteomes:UP000314987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Yazar S.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSVURP00010002198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Lipid droplet
CC {ECO:0000256|ARBA:ARBA00004502}.
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DR AlphaFoldDB; A0A4X2JRM6; -.
DR STRING; 29139.ENSVURP00010002198; -.
DR Ensembl; ENSVURT00010002511.1; ENSVURP00010002198.1; ENSVURG00010001828.1.
DR GeneTree; ENSGT00940000157197; -.
DR OMA; ILIRHQW; -.
DR Proteomes; UP000314987; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IEA:Ensembl.
DR GO; GO:0035473; F:lipase binding; IEA:Ensembl.
DR GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0034389; P:lipid droplet organization; IEA:Ensembl.
DR GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IEA:Ensembl.
DR GO; GO:0035617; P:stress granule disassembly; IEA:Ensembl.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:Ensembl.
DR CDD; cd02991; UAS_ETEA; 1.
DR CDD; cd14414; UBA_FAF2; 1.
DR CDD; cd16120; UBX_UBXN3B; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR049483; FAF1_2-like_UAS.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR006577; UAS.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001012; UBX_dom.
DR PANTHER; PTHR23322:SF105; FAS-ASSOCIATED FACTOR 2; 1.
DR PANTHER; PTHR23322; FAS-ASSOCIATED PROTEIN; 1.
DR Pfam; PF21021; FAF1; 1.
DR Pfam; PF14555; UBA_4; 1.
DR Pfam; PF00789; UBX; 1.
DR SMART; SM00594; UAS; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50033; UBX; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Reference proteome {ECO:0000313|Proteomes:UP000314987}.
FT DOMAIN 357..439
FT /note="UBX"
FT /evidence="ECO:0000259|PROSITE:PS50033"
FT REGION 302..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 445 AA; 52621 MW; 85DB92FC58FCCB2F CRC64;
MAAPEERDLT QEQTEKLLQF QDLTGIESMD QCRHTLEQHN WNIEAAVQDR LNEQEGVPSV
FNPPPSRPLQ VNTADHRIYS YVVSRPQPRG LLGWGYYLIM LPFRFTYYTI LDIFRFALRF
IRPDPRSRVT DPVGDIVSFM HIFEEKYGRT HPVFYQGTYS QALNDAKREL RFLLVYLHGD
DHQDSDDFCR NTLCSPDVVS LINNRMLFWA CSTNKPEGYR VSQALRENTY PFLAMIMLKD
RRMTVVGRLE GLIQPDDLIN QLTFIMDANQ TYLVSERLER EERNQTQVLR QQQDEAYLAS
LRADQEKERK KQEERERKRQ KEEEVQQQKM AEERRRRNLQ EEKERKSECL PPEPSPDDPE
SVKIIFKLPN DSRVERRFHF TQSLTVIHDF LFSLKESPEK FQIEANFPRR VLPCLPSEEW
PNPPTLQEAG LSQTEVLFVQ DLTDD
//
