ID A0A4X2K095_VOMUR Unreviewed; 351 AA.
AC A0A4X2K095;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Ileal sodium/bile acid cotransporter {ECO:0000256|ARBA:ARBA00013351};
DE AltName: Full=Apical sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00032438};
DE AltName: Full=Ileal Na(+)/bile acid cotransporter {ECO:0000256|ARBA:ARBA00033223};
DE AltName: Full=Ileal sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00030792};
DE AltName: Full=Na(+)-dependent ileal bile acid transporter {ECO:0000256|ARBA:ARBA00033014};
DE AltName: Full=Solute carrier family 10 member 2 {ECO:0000256|ARBA:ARBA00031381};
OS Vombatus ursinus (Common wombat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Diprotodontia; Vombatidae; Vombatus.
OX NCBI_TaxID=29139 {ECO:0000313|Ensembl:ENSVURP00010005384.1, ECO:0000313|Proteomes:UP000314987};
RN [1] {ECO:0000313|Proteomes:UP000314987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Yazar S.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSVURP00010005384.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) +
CC tauro-beta-muricholate(in); Xref=Rhea:RHEA:72179, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:133064; Evidence={ECO:0000256|ARBA:ARBA00034255};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) +
CC tauroallocholate(in); Xref=Rhea:RHEA:51840, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191406; Evidence={ECO:0000256|ARBA:ARBA00034234};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) +
CC taurochenodeoxycholate(in); Xref=Rhea:RHEA:71923, ChEBI:CHEBI:9407,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00034224};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) +
CC taurocholate(in); Xref=Rhea:RHEA:71875, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00034239};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) +
CC taurodeoxycholate(in); Xref=Rhea:RHEA:72087, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36261; Evidence={ECO:0000256|ARBA:ARBA00034280};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) +
CC tauronorcholate(in); Xref=Rhea:RHEA:71915, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191405; Evidence={ECO:0000256|ARBA:ARBA00034291};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) +
CC tauroursodeoxycholate(in); Xref=Rhea:RHEA:71927, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:132028; Evidence={ECO:0000256|ARBA:ARBA00034230};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71911, ChEBI:CHEBI:29101, ChEBI:CHEBI:29747;
CC Evidence={ECO:0000256|ARBA:ARBA00034231};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:71935, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29746; Evidence={ECO:0000256|ARBA:ARBA00034215};
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|ARBA:ARBA00011407}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A4X2K095; -.
DR Ensembl; ENSVURT00010006093.1; ENSVURP00010005384.1; ENSVURG00010004146.1.
DR GeneTree; ENSGT00950000182808; -.
DR OMA; RITTYVS; -.
DR Proteomes; UP000314987; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00841; bass; 1.
DR PANTHER; PTHR10361:SF19; ILEAL SODIUM_BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000314987};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 351 AA; 38758 MW; 5939D75BF36083CE CRC64;
MDASAWPTTI TAMNGSTCSS NATICDENSC VLPEDDYNRI LSTVLSIVIT TMLALVMFSM
GCNVEIMKFW GHIKRPWGIF VGFLCQFGIM PLTGFILSVA FDILPIQAVV VLIMGCCPGG
TASNILAYWT DGDMDLSISM TTCSTLLALG MMPLCLFIYT KMWTDTGLIK IPYDSLGISL
VALVIPVSVG IVVKNKWPEK AKIILKVGSI TGAILIVVIA VTGGILYQGA WIIHPKLWII
GTLFPFFGYL LGFILARAAG QSWQRCRTVS LETGMQNTQL CSTIVQLSFS QEELNQMFTF
PLIYSIFQLG MAGIFVGSKL CLQIQIEEDQ NNWNQYSPWG VFYLNKFRTF P
//
