ID A0A4X2L0I8_VOMUR Unreviewed; 2841 AA.
AC A0A4X2L0I8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Neurofibromin 1 {ECO:0000313|Ensembl:ENSVURP00010014717.1};
GN Name=NF1 {ECO:0000313|Ensembl:ENSVURP00010014717.1};
OS Vombatus ursinus (Common wombat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Diprotodontia; Vombatidae; Vombatus.
OX NCBI_TaxID=29139 {ECO:0000313|Ensembl:ENSVURP00010014717.1, ECO:0000313|Proteomes:UP000314987};
RN [1] {ECO:0000313|Proteomes:UP000314987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Yazar S.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSVURP00010014717.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 29139.ENSVURP00010014717; -.
DR Ensembl; ENSVURT00010016732.1; ENSVURP00010014717.1; ENSVURG00010011260.1.
DR GeneTree; ENSGT00550000074797; -.
DR OMA; TKEPYMF; -.
DR Proteomes; UP000314987; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0008429; F:phosphatidylethanolamine binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0021764; P:amygdala development; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
DR GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0021897; P:forebrain astrocyte development; IEA:Ensembl.
DR GO; GO:0048853; P:forebrain morphogenesis; IEA:Ensembl.
DR GO; GO:0061534; P:gamma-aminobutyric acid secretion, neurotransmission; IEA:Ensembl.
DR GO; GO:0061535; P:glutamate secretion, neurotransmission; IEA:Ensembl.
DR GO; GO:0048820; P:hair follicle maturation; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0033024; P:mast cell apoptotic process; IEA:Ensembl.
DR GO; GO:0070662; P:mast cell proliferation; IEA:Ensembl.
DR GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IEA:Ensembl.
DR GO; GO:0097529; P:myeloid leukocyte migration; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; IEA:Ensembl.
DR GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0002686; P:negative regulation of leukocyte migration; IEA:Ensembl.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0070667; P:negative regulation of mast cell proliferation; IEA:Ensembl.
DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0046929; P:negative regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:0035021; P:negative regulation of Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:1900148; P:negative regulation of Schwann cell migration; IEA:Ensembl.
DR GO; GO:0010626; P:negative regulation of Schwann cell proliferation; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0021915; P:neural tube development; IEA:Ensembl.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0098597; P:observational learning; IEA:Ensembl.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0043473; P:pigmentation; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0033027; P:positive regulation of mast cell apoptotic process; IEA:Ensembl.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0043535; P:regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:0045124; P:regulation of bone resorption; IEA:Ensembl.
DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:1900271; P:regulation of long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
DR GO; GO:0032228; P:regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0036135; P:Schwann cell migration; IEA:Ensembl.
DR GO; GO:0014010; P:Schwann cell proliferation; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
DR GO; GO:0021510; P:spinal cord development; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR GO; GO:1904738; P:vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:1990874; P:vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000314987}.
FT DOMAIN 1236..1452
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1581..1739
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 2492..2532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2786..2841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2514..2532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2803..2830
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2841 AA; 320066 MW; B5C235E488D6EEF1 CRC64;
MAAHKPVEWV QAVVNRFDEQ LPIKAGQQTT HTKVSTEHNK ECLINISKYK FSLVISGLTN
ILKNVNNMRI FGEAAEKNLY LSQLIILDTL EKCLAGQPKD TMRLDETMLV KQLLPEICHF
IHTYREGNQH AAELRSSASG VLFSLSCNHF NAVFSRISTR LQELTVCSED NVDVHDIELL
QYINVDCAKL KRLLQETVFK FKALKKVAQL AVINSLEKAF WNWVENYPDE FTKLYQTPQT
DMAECAEKLF DLVDGFAEST KRKAAVWPLQ IILLVLCPEI IQDISKDVVD EAKMNKKMFL
DNLRRALAGH GGSRQLTESA AIACVKLCKA STYINWEDNS VIFLLVQSMV VDLKNLLFNP
SKPFSRGSQN ADVDLMIDCL VSCFRISPHN NQHFKICLAQ NSPSTFHYVL VNSLHRIITN
SALDWWPKID AVYCHSVELR NMFGETLHKA VQGCGAHAAI RMAPSLTFKE KMTSLKFKEK
PTDLETRSYK YLLLSMVKLI HADPKLLLCN PRKQGPETQG STAELITGLV QLVPQSSMPE
IAQEAMEALL VLHQLDSIDL WNPDSPIETF WEISSQMLFY ICKKLTTHQM LSSTEILKWL
REILICRNKY LLKNKQSDRS SSHFLYLYGV GYDVSSGGGT SHISLDHEEF IRTCAQGPPL
RKVKGNSSMD GAIGSSGTPI CRQAQTKLEV ALYMFLWSPD IEAVLVAMSC FRHLCEEADI
RCGIDEISVH HFLPNYNTFM EFASVSNMMS TGRAALQKRV MALLRRIEHP TAGNTEAWED
TYAKWEQATK LILNYPKAKI EDGQVAESLH KTIVKRRMSH VSGGGSIDLC DADSLQEWIN
MTGFLCALGG VCLQHRSNAG FATYSPPMGP ISERKGSLIS MMSTDGNAET PVSKFMDRLL
SLMVCNHEKV GLQIRSNVKD LLGLELSPAL YPMLFNKLKS TISKFFDPQG QVLLTDTNTQ
FVEQTIAIMK NLLDNHAEGS SEHMGQASIE TMMLNLVRYV RVFGNLVQAI QIKTKLCQLV
QVMMERRDDL SFCQEMKFRN KMVEYLTDWV MGTSNQTADE DVKCLTRDLD QASMEAVVSL
LAGLPLQPEE GDGVELMEAK SQLFLKYFTL FMNLLNDCSE VEEESAQIGG RKRGMSRRLA
SLRHCTVLAM SNLLNANVDS GLMHSIGLGY HKDLQTRATF MEVLTKILQQ GTEFDTLAET
VLADRFERLV ELVTMMGDQG ELPIAMALAN VVPCSQWDEL ARVLVTLFDS RHLLYQLLWN
MFSKEVELAD SMQTLFRGNS LASKIMTFCF KVYGATYLQK LLEPLLRFVI TSSEWQHVSF
EVDPTRLEHS ESLEDNQRNL LQMTEKFFHA IVGSSSEFPP QLRSVCHCLY QATCHSLLNK
ATVKEKKENK KSVVSQRFPQ NSIGAVGSAM FLRFINPAVV SPYEAGILER KPLPRIERGL
KLMSKILQSI ANHVLFTKEE YMRPFNDFVK SNFDVARRFF LDIASDCPVS DAINHSLSFI
SDGNVLALHR LLWNNQEKIG QYLSSNRDHK AVGRRPFDKM ATLLAYLGPP EHKPVADTHW
SSLNLTSSKF EEFMTRHQVH EKEEFKALKT LNIFYQAGTS KAGNPVFYYV TRRFKTGQIN
GDLLIYHVLL TLKPYYAKPY EIVMDLTHAG PSNRFKTDFL SKWFVVFPGF AYENVSSVYI
YNCNSWVREY TKYHERLLTG LKGSKRLFFI DSPAKLAEHI DYDQQKLPAA TLALDEDLKV
YNSALKLAHK DTKVTLKVGS TAIQVTSSER TKVLGQTVFL NDIYYASEIE EICLVDENQF
TLTISNQGTP LTFMHQECEG IVASIIHIRT RWELSQPDSI PQHTKIRPKD VPGTLLNIAL
LNLGSSDPSL RSAAYNLLCA LTCTFNLKIE GQLLETSGLC IPANNTLFIV SISKTLAANE
PHLTLEFLEE CISGFSKSSI ELKHLCLEYM TPWLSNLVRF CKHNDDAKRQ RVTAILDKLI
TMTINEKQMY PSIQAKIWGS LGQITDLLDV VLDSFIKTSA TGGLGSIKAE VMADTAVALA
SGNVKLVSSK VIGRMCKIID KTCLSPTPTL EQHLMWDDIA ILARYMLMLS FNNSLDVAAH
LPYLFHVVTL LVATGPLSLR ASTHGLVINI IHSLCTCSQP HFSEETKQVL RLSLTEFSLP
KFYLLFGISK VKSAAVIAFR SSYRDRSFSP GSYERETFAL ASLETVTEAL LEIMEACMRD
IPACKWLDQW TELAQRFAFQ YNPSLQPRAL VVFGCISKRV SHGQIKQIIR ILSKGLESCL
KGPDNYNSQV LIEATVIALT KLQPLLNKQE SPLHRALFWV AVAVLQLDEV DLYSAGTALL
EQNLHTLDSL LHVFNDQSPE EVFMEIRQPL EWHCKQMDHF VGLNFNSSFN FALVGHLLKG
FRHPSPVTVA RTVRILHTLL ALVNKHRNCD KFEVNTQSVA YLAALLTVSE EVRSRCSLKH
RKSLLLTDIT VENVPMDIYP IYHSDPSLRT LKETQPWSSP KGSERHLAAS YPPVGQTSPR
TRKSMSLDMG QPSQANTKKL LGTRKSFDHL ISDAKAPKRQ EMESGVTTPP KMRRVAENDY
EMETQRISPQ PHLPLRKVSV SESNVLLDEE VLTDPKTQAL LLTVLATLVK YTADEFDQRI
LYEYLAEASV VFPKVFPVVH NLLDSKINTL LSLCQDPNLL NPVHGIVQSV VYHEEAPPQY
QTAYLQSFGF NGLWRFAGPF SKQTQIPDYA ELIVKFLDAL IDTYLPGIDE EGSEESLLTP
TSPYPPTVQS QLSITANLNL SNSMTSLATS QHSPGIDKEN VELSPTTGHS SSGRTRHGSA
SQVQKQRSAG SFKRHSIKKI V
//
