ID A0A4Y0AS73_ANOFN Unreviewed; 880 AA.
AC A0A4Y0AS73;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Sorbin and SH3 domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN003375-PC, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN003375-PC}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN003375-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A4Y0AS73; -.
DR STRING; 62324.A0A4Y0AS73; -.
DR EnsemblMetazoa; AFUN003375-RC; AFUN003375-PC; AFUN003375.
DR VEuPathDB; VectorBase:AFUN003375; -.
DR VEuPathDB; VectorBase:AFUN2_005249; -.
DR OrthoDB; 5407056at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd11781; SH3_Sorbs_1; 1.
DR CDD; cd11782; SH3_Sorbs_2; 1.
DR CDD; cd11780; SH3_Sorbs_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR PANTHER; PTHR14167:SF114; CAP, ISOFORM AC; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF14604; SH3_9; 3.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 4: Predicted;
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 258..331
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 624..683
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 696..755
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 821..880
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..119
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..515
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 98735 MW; C1FEA3933D21F3F5 CRC64;
MGQDSGTAVK IAPKFKAKTS SLGVWSPFNR STEVLTKAEL AERSPAQNEA NASQQPPVWT
PRSAPPSPLS ERREFRRIGF ESPTPTRRTI TPSPADPSAV VTPPWNQPGY NPPLAVAEPS
KPIPIQSSAS SGALVSSAKV TTPPPPPPEA GYQQVRFPPL PRSANTQEPT INSLLKSKDG
KTATLKGSEA AESLKKVSTV TASTVRTSSS LMTNNSQLGS VVNTSQTNYQ NPPLRHKAEQ
SIASLQATTD MQDRQMQQSP ANKVEGIGPI SREGMPLTLR SEIDERNRDK WYKQMYQTLH
KTHEDGYPYK SSGYQSEPEP NYDSDYSIKY STLDRRRTPV GLSPTSYNKF NTLQSKPTTP
QQYHQQSVKS GQVSYKNQPG RIEDYTPGRS SISEKESKEW WDEVMDIFNG QLEHQKISGK
TYTEGNLSRA LKEQGYESDS TLVFRKREPP VSAALSPVEQ KQYYKTMQAG GEIPLQGFRK
PAPERPKEPH ITFPSPPLKG AQPPPPPPPP LPTLISSSPI ATSVNGAESP RRYIESDVNI
HYKTPVRFEY KDPIPDDELA YRQAEHMRRV YQEERRRKYM HELEDMHSRR HMDNILPSQK
SPIPLNRYDD FPADLSVKPQ IVQQPKTIAR ALYNFQGQSV RELSFRKGDI IYLRRQIDKN
WYEGEHNATV GLLPANYIEI LSRDNVNVRP LPKKPSREGK ARAKFNFTAQ TTVELSLLKG
ELVTLTRRVD DNWFEGKIGN KKGIFPVSYV EILTDIDGEE SYDIEPIASR PQSALGVTSE
SSRALTTHYD NSHTNGRISP GIVRETKTIQ KTEVLHVDTS NEPISYRALY NYKPQNTDEL
ELLEGDVVYV LEKCDDGWYV GTSARSGCFG TFPGNYVTKL
//
