ID A0A4Y0AUP8_ANOFN Unreviewed; 756 AA.
AC A0A4Y0AUP8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AFUN004626-PB};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN004626-PB, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN004626-PB}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN004626-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A4Y0AUP8; -.
DR STRING; 62324.A0A4Y0AUP8; -.
DR EnsemblMetazoa; AFUN004626-RB; AFUN004626-PB; AFUN004626.
DR VEuPathDB; VectorBase:AFUN004626; -.
DR VEuPathDB; VectorBase:AFUN2_001349; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00153; RA_RalGDS_like; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 67..194
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 239..500
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 651..741
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 497..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 756 AA; 84229 MW; 2B6BC54D5B67FEE4 CRC64;
MSNGTATSGT GGDADSLPTW RLWGEEREEN AIYTVYLKKV RYHRPTPSAS SQDSDDEISH
LEWETVRVRF VKAATLARLV DALATDDGEL ESTFVNVFLN TYRTFAQPEK VLELLLDRYE
KLHAEPALLQ PESLSDQHKK TLVSVLHVWL DGFPEDWDTD NLQRLLAFTS KRLPKSEIHM
KALNRFTHRL DKYSRIPPPL PWSNDYHDFA DQFGGLCLTP AFRGPPSHLL NSYRFPNIPV
KHFAEQLTRM DMELFKRLIP HQCLGAIWSN RDKHECSSVL ATVTQFNAVS FRVISSILIE
PRLKPQERAL LISTWIDIAQ ELRLLKNFSS LKAIISGLQS NAVYRLSKTW AVLPRDKLEL
YNELARIFSE DNNAWAQREV LMREGTAKFA DTVGENDRHL QKVFQKQNTL ISHGTIPYLG
TFLTDLTMIH AAIPDTLQDG LINFDKRRKE FEVLAQIKLL QGAANTYHLP DDPLFDRWFA
SLLVLDEREA HTLSCSLEPA PEMTKRPPTQ HPGGGTGGGG GGTPGHKKSD SIASNSSSGA
GSQFYCDINS TSNASYSSRN NSLDRDATPP NASILSAASS VSSLSMDSTT SGSQRSNHNG
GVGSVRTPQS NRSQANGTVA NRSANGTRDL EAPIINGQLV QNSPLKSSSP DFYIIKVTYE
TEQVELDGIV LYKSIMLANN ERTPQVIRNA MLKLGLEGDP DRYTLAQVLP DKELLLPNNA
NVYYAVNTAY NLNFILRPKK DTTGSSSSVP SSTGRP
//