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Database: UniProt
Entry: A0A4Y0AUP8_ANOFN
LinkDB: A0A4Y0AUP8_ANOFN
Original site: A0A4Y0AUP8_ANOFN 
ID   A0A4Y0AUP8_ANOFN        Unreviewed;       756 AA.
AC   A0A4Y0AUP8;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   13-SEP-2023, entry version 16.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AFUN004626-PB};
OS   Anopheles funestus (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN004626-PB, ECO:0000313|Proteomes:UP000075900};
RN   [1] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA   Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA   Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA   Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT   "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT   Middle East: occurrence data, distribution maps and bionomic precis.";
RL   Parasit. Vectors 3:117-117(2010).
RN   [2] {ECO:0000313|Proteomes:UP000075900}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX   PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA   Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA   Besansky N.J.;
RT   "A chromosome-scale assembly of the major African malaria vector Anopheles
RT   funestus.";
RL   Gigascience 8:0-0(2019).
RN   [3] {ECO:0000313|EnsemblMetazoa:AFUN004626-PB}
RP   IDENTIFICATION.
RC   STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN004626-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A4Y0AUP8; -.
DR   STRING; 62324.A0A4Y0AUP8; -.
DR   EnsemblMetazoa; AFUN004626-RB; AFUN004626-PB; AFUN004626.
DR   VEuPathDB; VectorBase:AFUN004626; -.
DR   VEuPathDB; VectorBase:AFUN2_001349; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000075900; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00153; RA_RalGDS_like; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168}.
FT   DOMAIN          67..194
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          239..500
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          651..741
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          497..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..625
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  84229 MW;  2B6BC54D5B67FEE4 CRC64;
     MSNGTATSGT GGDADSLPTW RLWGEEREEN AIYTVYLKKV RYHRPTPSAS SQDSDDEISH
     LEWETVRVRF VKAATLARLV DALATDDGEL ESTFVNVFLN TYRTFAQPEK VLELLLDRYE
     KLHAEPALLQ PESLSDQHKK TLVSVLHVWL DGFPEDWDTD NLQRLLAFTS KRLPKSEIHM
     KALNRFTHRL DKYSRIPPPL PWSNDYHDFA DQFGGLCLTP AFRGPPSHLL NSYRFPNIPV
     KHFAEQLTRM DMELFKRLIP HQCLGAIWSN RDKHECSSVL ATVTQFNAVS FRVISSILIE
     PRLKPQERAL LISTWIDIAQ ELRLLKNFSS LKAIISGLQS NAVYRLSKTW AVLPRDKLEL
     YNELARIFSE DNNAWAQREV LMREGTAKFA DTVGENDRHL QKVFQKQNTL ISHGTIPYLG
     TFLTDLTMIH AAIPDTLQDG LINFDKRRKE FEVLAQIKLL QGAANTYHLP DDPLFDRWFA
     SLLVLDEREA HTLSCSLEPA PEMTKRPPTQ HPGGGTGGGG GGTPGHKKSD SIASNSSSGA
     GSQFYCDINS TSNASYSSRN NSLDRDATPP NASILSAASS VSSLSMDSTT SGSQRSNHNG
     GVGSVRTPQS NRSQANGTVA NRSANGTRDL EAPIINGQLV QNSPLKSSSP DFYIIKVTYE
     TEQVELDGIV LYKSIMLANN ERTPQVIRNA MLKLGLEGDP DRYTLAQVLP DKELLLPNNA
     NVYYAVNTAY NLNFILRPKK DTTGSSSSVP SSTGRP
//
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