ID A0A4Y0AV98_ANOFN Unreviewed; 960 AA.
AC A0A4Y0AV98;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE SubName: Full=UDENN domain-containing protein {ECO:0000313|EnsemblMetazoa:AFUN004745-PB};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN004745-PB, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN004745-PB}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN004745-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A4Y0AV98; -.
DR STRING; 62324.A0A4Y0AV98; -.
DR EnsemblMetazoa; AFUN004745-RB; AFUN004745-PB; AFUN004745.
DR VEuPathDB; VectorBase:AFUN004745; -.
DR VEuPathDB; VectorBase:AFUN2_008131; -.
DR OrthoDB; 5398783at2759; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.140.1000; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR040032; DENND1A/B/C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR13196:SF14; UDENN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}.
FT DOMAIN 14..374
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 435..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 884..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..807
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..934
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 106188 MW; C9150A35FA34EC5C CRC64;
MNSRIKEDVS RLFEFWCEIA PGTADDTAPG HIVESFPESF KDAKVIADIP AFAFPCAFES
RTIQVHSFVL TNIDSKWRFG FCRHDPKSPT AMVIITYLPW HDTFMRFLNV LADIRKNRPN
EFPSFLAESY NKGVPEPGAC LKLHYDRASQ TFLFQRPQQF QLPSIPENHN LNQYYNFVEP
KFMIGIFAAM LAERRIIFVS RRLDILSSCV QAANAFLYPM VWQHIFIPVL PMKMKEILDA
PMPFLIGVPE AVYETLQREE IGDVVILNCD KRTLDTPFDD VKSMPQELVS SLKKQLSNQA
DHRGDRVSKI FLGILVQLIG GYRDAVKFND KITFDPETFI ESRPSHLRPF LDKMLDLQIF
QQFIEERLDM LNTGQGFSDE FEVEYFRYAE KSGRKTKQYK DLLKNFKDKT NPAVRSAVKS
VKEGGKGVKT AYKGLRSKFR ETTPPKTKLD SSSSLHLHHQ YDVGGHHQSA PNSPVFNKRP
QTIALPDDVY HTHNPHQMLT PSSTSLHNSP HILLGSHHHQ HHLHQSLPQS NGGVGGGSAG
NSSSAGYHSA SAAMTRSGSS AAGSTSHMNN NNHSYANSSN NNNNHMTSSS ASDIRSPTLS
PTSSNSSSEM NLWQEMQHHL TLFKSPAVNR NLKPTNSAEG GNTGSRPSSR AGAPVSPPGG
SSNALPRIQE SVAVGTQPLL SLELNDARQH TGRPYNSCNN NGSGDYHNED DQTNFDLSPD
APCPPIPPRR FQSAADALAA IQISPPPMSP PSSSSSNSSP YRTYNNFIPA VAKAKPPIAV
PSGTSSPSII DQSPPLPSPP PPPPLKAQVD TSIRRNDILQ FDDEEEQLIT LTTTMTTVGG
YAGTATTTTT SMSMTFGQPV GRNHELAPTS NSTMHNSHIL PSLLPQTQHP KQQPNVQTVP
ATAGKTPPLQ HAYTLPHPPK AQAPQPPQRP PLAPKPTFRK EMRVKIERKL SMQTVAKQDV
//
