ID A0A4Y0BDB0_ANOFN Unreviewed; 459 AA.
AC A0A4Y0BDB0;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=U-box domain-containing protein {ECO:0000259|PROSITE:PS51698};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN018805-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN018805-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN018805-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR AlphaFoldDB; A0A4Y0BDB0; -.
DR STRING; 62324.A0A4Y0BDB0; -.
DR EnsemblMetazoa; AFUN018805-RA; AFUN018805-PA; AFUN018805.
DR VEuPathDB; VectorBase:AFUN018805; -.
DR VEuPathDB; VectorBase:AFUN2_013687; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46573; WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46573:SF1; WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00504; Ubox; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51698; U_BOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 13..43
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 59..100
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 280..312
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 321..362
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 380..454
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
SQ SEQUENCE 459 AA; 50201 MW; 3FF2C7B37132CD3C CRC64;
MSAAKTTTIL QKLTAHTSDV TSLDFYGNAL LVTGSSDKTV RVWRWVAGNG FREESFSPLL
GHRYGVTGVR VSPKGAVLAS ASVDGTVILW NLSNGEISNV INQEGGEAIR ACIFSPNGST
IVSSDDNGSV CIWAQDKSLK CHVKVHDEAV HTIAFSSDSD ILLTACTLGN VRLYAVENDF
AGDLSSADCS IDAAHDMGVL SADFCKIVHT DPTDKCSLIY TVATCGTDHY IKIWRIFFMP
NNIDRSRRSR LIPTSPQEHF AGQSTIYSTE VMNASCVQTI SAHGSSVTCV RFNPTGTLLF
SCSLDKTIKI WNQQGTCLKT LSEHSRYVNC LAINSDSSVI ASGSNDRTVV VWDLTSRLSL
NSHITGIRSL LFSLAVKTAD IPLEFTCPIT HELMKDPVYA EDGFTYERSA IKEWFSREKA
ISPMTNLELS TDELVENGKL KQQIEDYMRS LDTDVGEVN
//
