ID A0A4Y0BM43_ANOFN Unreviewed; 1026 AA.
AC A0A4Y0BM43;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN020822-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN020822-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN020822-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; A0A4Y0BM43; -.
DR STRING; 62324.A0A4Y0BM43; -.
DR EnsemblMetazoa; AFUN020822-RA; AFUN020822-PA; AFUN020822.
DR VEuPathDB; VectorBase:AFUN020822; -.
DR VEuPathDB; VectorBase:AFUN2_009165; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF713; UNCONVENTIONAL MYOSIN ID; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 9..692
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 808..1005
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 569..591
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 102..109
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1026 AA; 118537 MW; 6AA455AF26950D4C CRC64;
MAHHQGQEVG VQDFVLLDSV TQENFMDNLK RRFQAGKIYT YIGEVCISVN PYREMNIYGP
EYVNRYKGRE LFENAPHIFA IADAAYRVLK QRNNDTCIMI SGESGAGKTE ASKIIMKYIA
AVTNQGKQGE IERVKNVLIK SNAILECFGN AKTNRNDNSS RFGKYMDIEF DYKGDPVGGI
ITNYLLEKSR VIQQQIGERN FHCFYQLLRG GSNNELQQYN LVRDPGAYHY TNQGSTEVLS
EKSDYRATTG GLQALGFSAD EISMVWRTVA AILHLGNIEF QMKDEKITIT NGKTLAQVAQ
LLQVTAEEMR TALTERVIAA RGEIMTKSHD TKQAEYGRDA LAKAIYDRMF TWIIQRINKA
ILVPGSTTQK RYNKVIGVLD IYGFEIFDRN SFEQFCINYC NEKLQQLFIE LVLKQEQEEY
NREGIEWTNI EYFNNQIICA LVEQADKGVI AIMNEACLNV GKITDEMLLG DMDKKLSHHP
HYSSRQLKPM DKELRHKEDF RITHYAGDVI YSISGFIEKN RDTLFQDFKR LLYGSHDKLI
SSMWPEGAQD ISKTTKRPLT AGTLFQKSMA ELVATLLRKE PLYVRCVKPN DIKSPTVFDD
VRVEHQVRYL GLLENVRVRR AGFVHRQRYD KFLLRYKMIS QYTWPNFRGG NDRDGVKVLM
NEKNFSHDVR FGKTKIFIRS PQTLFALEQQ RNDMIPHIVT LLQKQVRGWI ARQKYKKMKA
ALVIMRHYRK YKLKSYVQDL AVRFRNARTL RDYGKGIQWP QPPLVGRQAE RHLRMLFSRW
RAAMILRKYP REEWPQLRLQ IIAASAFRKR RKFWGHDRRW LGNYLSIVAE NSNYSSYNAS
VRNIKNTDHF DTIVFSAFVK KFNKCNKSAD RAIIVTDGAI YKLDGAKNKF RNMKRTVPIR
EITSISVSPG RDQLAVFHSH HNNDLIVSLQ GEHQPLKEDR IGELVAHVVR RYFAICQQDL
PVNVASTFPL RLGNKSRSLN IEAAVGQDLP EFSHAGTFIV FKVPPAYASP LESTETSAPN
TLPQRY
//
