ID A0A4Y0BNG5_ANOFN Unreviewed; 2986 AA.
AC A0A4Y0BNG5;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 08-NOV-2023, entry version 17.
DE RecName: Full=Neurofibromin {ECO:0008006|Google:ProtNLM};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN020113-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN020113-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN020113-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 62324.A0A4Y0BNG5; -.
DR EnsemblMetazoa; AFUN020113-RA; AFUN020113-PA; AFUN020113.
DR VEuPathDB; VectorBase:AFUN020113; -.
DR VEuPathDB; VectorBase:AFUN2_014567; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
FT DOMAIN 1242..1437
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 1573..1731
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 834..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2456..2508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2725..2744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2918..2957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2465..2508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2730..2744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2930..2945
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2986 AA; 334097 MW; B8D9E9B27C97196A CRC64;
MATQKPGEWA NSLLARFEEQ LPYRTGPHGT QARLSIDETM NCLIQISRYR FSLVISGLTK
MLQRVNEIFQ PPACRGHEPE RCCYDSLIII LETLERCLSG QSKDTARFEE AMNVKLLLRE
ICQFIDIQNE NNQNATSLKA LASKVLFALS QNHFGAVFNR ISARLQELST CAEENPDYSD
IELIQHIDLD VHRLTKLLTE TIQKFKSLKK SAHMILLSSL EKALWNWIEF HPKEFEDLQR
NPNDELSKCC ETFFDILDSY SENKKARAAV WPLQIMLLIL SPKVLEEIVN ADSGAPCSPR
HLKKKHFMEG IKKGLGAHAS SKQSTESAAI ACVKLCKAST YININDSNNV TFQLVQSVIN
DLKALLFNPA KPFSRGQGFN FQDIDLMIDC WVSCFRIKPH NNEALKVCLS LNSPPAYHFV
IVSSLLKIVT QARLPWWPQI DLVYARSGEL RGLFTDTLNK ATQGYIAHTP LRMITSLTLK
SKDAQSRLTR PDEGPAHKAL LLLMVRLIHA DPMLLLNSLG KAGHEVQSST LELINGLVSL
VHQPTMPDVA QEAMEALLAL HSPDKIEVWN PEAPINTFWD VSSQVLFSIS QKLIQHQIAN
YTDVLKWLRE ILICRNTFLQ RHKDYANVGS QIAICRQAHI KLEVVFFMYL WSVDLDAVMV
SLSCFGLLCE EAEIRSGSDE LTVGFILPNY HLYQELSHTS ATLTSPQNAE SRYSFFEHLH
GRVTLQRNIM SLLRKIEHCV NGVQPAWEET FRNWEVTSKL LQNYPKGKPE EGQAEVFHRS
MGKRRASHQS SEHDLEEQIT EWANMTWFLL ALGGVCLQKP RNQRQTAQGY NLPLGTAGPS
LMQSTTSLSS SSSGRGSMHP IMGSLVSSIG PGSSQEVQYC PVTQFIGQLL RLLVCNNEKF
GPQIQKHVKE LVGQEMSAQL YPILFDQIRS IVEKFFDQQG QVVVTDINTQ FIEHTIYIMK
SVLDGRQSKD QNDQPANAEH LGVTSIENLM LAIVRYVRHL DMTVHAIHIK TKLCQLVEVM
MKRRDDLAFR QEMKFRNKLV EYLTDWVMGT SHQIAPPGSG DVTIITRDLD QACMEAVAAL
LRGLPLQPEE SDRGDLMDAK SALFLKYFTL FMNLLNDCVD GSEADKDTNN PPLLPPRPRV
AAGKLTALRN ATIQAMSNLL SANIDSGLMH SIDLGYNPDL QTRAAFMEVL TQILQQGTEF
DTLAESVMAD RFEQLVQLVT MISDKGELPI AMALASVVTT SQMDELARVL VTLFDAKHLL
SPLLWNMFYR EVEVSDCMQT LFRGNSLGSK IMAFCFKIYG ASYLQGLLEP LIRPLLEEPT
SSFEVDPARI EPSEDIEVNR KNLIALTQKV FDAIVNSADR FPPQLRSMCH CLYQVLSKRF
PNLLQNNIGA VGTVIFLRFI NPAIVSPQEL GIVGKQVPTQ IKRGLMLMSK ILQNIANHVE
FSKEQHMLCF NDFLRAHFEA GRRFFIQIAS DCETVDQTSH SMSFISDANV LALHRLLWSH
QERIGDYLSS SRDHKAVGRR PFDKMATLLA YLGPPEHKPV DSHLLFSSYA RWSSIDMSST
NFEEIMVKHQ MHEKEEFKTL KSMNIFYQAG TSKAGNPVFY YIARRYKIGE TNGDLLIYHV
ILTLKPFCHS PFEVVIDFTH TCSDNRFRTE FLQKWFYVLP EVAYENLYAA YIYNCNSWVR
EYTKFHDRIL APLKGCRKLI FLDSPAKLND VIDPEQQKLP GATLSLDEDL KVFNNALKLS
HKDTKVAIKV GPTALQITSA EKTKVLAHSV LLNDVYYASE IEEVCLVDDN QFTLSIANES
SQLSFIHNDC DNIVQAIIHI RNRWELSQPD SVTVHQKIRP KDVPGTLLNM ALLNLGSSDP
NLRTAAYNQL CALTATFDLK IEGQLLETQG LCIPSNNTIF IKSVSETLAT NEPHLTLEFL
EECIQGFQRS TIELKHLCLE YMTPWLANLV RFCKPSDEGK RQKQVALILE KLINLTIEQK
EMYPSIQAKI WGSIGQIPEL IDMVLDNFIH KSVSSGLGSP QVEIMADTAV ALASANVQLV
AKKVIGRLCR VMDKTCHSPT QYLEQHMMWD DIAILARYLL MLSFNNCLDV ARHLPYLFHT
VTFLVCTGSL SMRASTHGLV INIIHSLCTC TKPSFSEETQ RVLRLSLDEF SLPKFYLLFG
ISKVKSAAVT AFRSSCRHPN DRWLGNERVS QAPPADRERL ALPSLEVITE ALLEIMEACM
RDIPDCDWLQ TWTSLAKSFA FCFNPALQPR ALIVFGCISK SVTDQDVKQL LRILVKALES
FNDIILLEAL VMCLTRLQPL LRPESPIHRA LFWVAVSVLQ LDESTLYAAG LALLEQNLHT
LNSQQLFDNQ NIADVMMATR EPLEWHFKQL DHAVGLSFKS NFHFALVGHL LKGFRHPTPT
TVSRTSRVLT MLLGIVAKPH RRDKFEVTPD SVAYLTALVC FSEEVRSRCH VKHTVPRWPV
ESGGSGDSGS GSSSDPSAPN SAGGGPLSGG SSAVTSSTSG GNSVRRQKSW DMLDQSAIQY
ARQSHKVQQH QEPVVIRGKS WRSLDSAHNP HLGMISHSSF VTHGNTTTTT TNNNNINNNM
INMNSNTSNS ITIGMTNLNN SSIITNISSN TNNSSTTSST FATASTTAAS AANVAASIGI
GAYQSQRNDF RNRRSSSEPV NHGQMVLINP NVAKLIALNQ GHTPTYGYGA NVGGAATVAH
TFACGQPAQP TSPLPPVIGT VSTMPTADEE ASEQTRDAAK QGTKDESENF IVDCLQDISS
IKERGSRSSV SNESNVLLDP EVLPDSSTQA LVLTVLATLV KYTTDEAETR VLYQYLAEGS
IVFPKVFPVI HSLLDQKVNN VLSVSNDQIV LASVQSIIQN MLASEDASQQ PLHFLQSCGF
GGLWRFAGPF TKYNMMVESS ELFVNFLEAM VETCLPVEET TPMPPSPRPY NLSSSLSSLT
LGSPTDKESL DHDGFSGSVS SLRRASCSKA RTGTKHRFID SPTHNI
//
