ID A0A4Y0BNW4_ANOFN Unreviewed; 1382 AA.
AC A0A4Y0BNW4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:AFUN021442-PA};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN021442-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN021442-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN021442-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 62324.A0A4Y0BNW4; -.
DR EnsemblMetazoa; AFUN021442-RA; AFUN021442-PA; AFUN021442.
DR VEuPathDB; VectorBase:AFUN021442; -.
DR VEuPathDB; VectorBase:AFUN2_014077; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 433..568
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 676..766
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1289..1378
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1382 AA; 153362 MW; 50D00FBD8DE02382 CRC64;
MPFGGEPKRT VPDPKDHKDG HYSIIGARII RPNSVYRALV STFDAKSAIA FRISIVAKEK
IIKSEEITLN GSESRLLSFT IDSIPEEEYE LVAEGLSGLV FKTKTGLDFD NKFCSVLIQT
DKSVYKPGDT VRYRVLVLDR YMKPLPANAT MMVYIRDGKG NRIKQWNNAS LGECGVFQSE
LTLSTEPVLG EWDINVDVLG LKAFKSFDVD EYVLPTYEVT VESPGYTFLD DDVLKVVVNS
KYTYGKPVVG ELTLSVKLGS SMCFRRGSNA TNICQKVVPI DGKTVVEFNL KEILLNKAYI
RELEIVGEVC ETLTGRIQKG STSVTLHDDR YKVRMIEESQ YFPGLPYAAW IQVTNLDGSP
VQEGTNDVEI SLRNYNTDLF KEVTTLDDKG MAKLNAKLDE LDFDYLSVGV KYRGKDYHVQ
GITKLRSDEE AFMRTLPLEK KTMPGKELKF DVACTKPLQF VAYTLLARGE LLVGGAVEGS
DNKTISITIP STYCMVPRAK LLVHYISTAG YIVSSYAKVK FEKLFENKIH LNLSKDELKP
GEPLDIDVQT EEGSFVGLLA VDQSVLLLKS GNDISSEQIE QELEKYESAQ NCHGFWDGSN
TSDCQAVGAV LLSNRFIPQE MYPQARMFKC SAPVGMAGGF GAAPMMLRSA KMAVMESDTF
VEPAQEPTVR ANFPETWIWE SIVNCKDMQS IRKIVPDTIT SWVITGFSLS NSHGLGLMDA
PSKVNVFMPF FLSIDLPYSV KLGETVRIPV IVFNYMDEDQ QADIVFFNND GEFEFISEEA
GDHKEKHRQE KLSVSRGSGK TLTFMIKPTK VGHITLKITA KCALAGDGIE RQLLVEPEGL
PQYVNKALLV DLRSAKDIRQ TFEVEVPEDA VPDSTKVEVS VIGDVLGSSI ENLDSLIRMP
FGCGEQNMLN FVPCIVVLDY LKACRRLTVE IESKAKKCME VGYQRELTYK HQDGSFSAFG
ESDKSGSTWL TAFVAKSFQQ AAHHITIEED VIDKALSWLS KVQSSDGAFP EVGSICHKDM
QGGAGSGIAL TAYTVVAFLE NAKLAEKFKS TVDKALTYIK DHIGELDDVY AHALAAYALQ
IAKHPLKDEV SASLQSKAKK EGDMQWWTKA LPEKNNSDCC WYRPCSVNVE MSAYGLLATL
ETSTGLEGLP IMKWLVSQRN DKGGFESTQD TVVGLQALSK IAAQLSSSEA DVSIKVMLPT
GQEKLLSVNR DNLLVLQKHE LAANTRKVDM LATGTGCSLF QLSYKYNIKD TDNSPRFTLT
PEATKGSIKS CIDLSVSTSF IPKDDQVVSN MAVMEVDMPS GFIVESDALK QLKEHELVKK
VETKRGNTTV VLYFDNVGAD IIKLSMSAFQ KHEVENAKPA NVIIYDYYDN TRCARSFYEV
AV
//
