ID A0A4Y0BW92_ANOFN Unreviewed; 257 AA.
AC A0A4Y0BW92;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=Transmembrane protein 192 {ECO:0000256|ARBA:ARBA00014635};
OS Anopheles funestus (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=62324 {ECO:0000313|EnsemblMetazoa:AFUN022216-PA, ECO:0000313|Proteomes:UP000075900};
RN [1] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=21129198; DOI=10.1186/1756-3305-3-117;
RA Sinka M.E., Bangs M.J., Manguin S., Coetzee M., Mbogo C.M., Hemingway J.,
RA Patil A.P., Temperley W.H., Gething P.W., Kabaria C.W., Okara R.M.,
RA Van Boeckel T., Godfray H.C., Harbach R.E., Hay S.I.;
RT "The dominant Anopheles vectors of human malaria in Africa, Europe and the
RT Middle East: occurrence data, distribution maps and bionomic precis.";
RL Parasit. Vectors 3:117-117(2010).
RN [2] {ECO:0000313|Proteomes:UP000075900}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FUMOZ {ECO:0000313|Proteomes:UP000075900};
RX PubMed=31157884; DOI=10.1093/gigascience/giz063;
RA Ghurye J., Koren S., Small S.T., Redmond S., Howell P., Phillippy A.M.,
RA Besansky N.J.;
RT "A chromosome-scale assembly of the major African malaria vector Anopheles
RT funestus.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EnsemblMetazoa:AFUN022216-PA}
RP IDENTIFICATION.
RC STRAIN=FUMOZ {ECO:0000313|EnsemblMetazoa:AFUN022216-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMEM192 family.
CC {ECO:0000256|ARBA:ARBA00006314}.
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DR AlphaFoldDB; A0A4Y0BW92; -.
DR STRING; 62324.A0A4Y0BW92; -.
DR EnsemblMetazoa; AFUN022216-RA; AFUN022216-PA; AFUN022216.
DR VEuPathDB; VectorBase:AFUN022216; -.
DR VEuPathDB; VectorBase:AFUN2_002412; -.
DR Proteomes; UP000075900; Unassembled WGS sequence.
DR GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029399; TMEM192.
DR PANTHER; PTHR31592; TRANSMEMBRANE PROTEIN 192; 1.
DR PANTHER; PTHR31592:SF1; TRANSMEMBRANE PROTEIN 192; 1.
DR Pfam; PF14802; TMEM192; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 228..255
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 257 AA; 29420 MW; E0E7E4F01DF85852 CRC64;
MSTHSESPLQ SNNSKLYSPP NLSDHSLRFR PVLVICLFSV HLFFAILIVV VGTIASALSL
PHPSDDASSV YFIIIYLRIS YWVVTYVIHE QNKREFVRLA EPDFDHYRSL TVYRKAPLQI
ATLWNVILLT VQNQVRYLFP YEHHDTSGTN SGNDRNAAGG ALNPAITPQV FVIVVCSLEL
LVLLCFYVPL VRILIDIRKS EGHGKVTDLR YRRMTETELA EQPIEWQLER QAILIKSLRT
KRDSLEREAK LLGIDQC
//
