ID A0A4Y6E9L3_9CAUD Unreviewed; 269 AA.
AC A0A4Y6E9L3;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN Name=3 {ECO:0000313|EMBL:QDF15365.1};
GN ORFNames=SEA_MOLLYMUR_3 {ECO:0000313|EMBL:QDF15365.1};
OS Gordonia phage Mollymur.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Bantamvirus.
OX NCBI_TaxID=2590895 {ECO:0000313|EMBL:QDF15365.1, ECO:0000313|Proteomes:UP000319811};
RN [1] {ECO:0000313|EMBL:QDF15365.1, ECO:0000313|Proteomes:UP000319811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Murphy M.E., Alvaro L.E., Baker K.N., Baxter I.S., Brown M.R.,
RA Driscoll K.D., Elrubaie J.M., Feith S.L., Indihar D.F., Knoch V.T.,
RA Koirtyohann K.M., Kratz M.A., Lear A.H., Lindblom K.E., Marcus E.R.,
RA Sensor R., Sherman S.J., Swift V.R., White K.E., Wills S.J., Gatt S.M.,
RA Lohbauer S.A., Power T.R., Rosales K.A., Sisson B.M., Isern S.,
RA Michael S.F., Monti D.L., Garlena R.A., Russell D.A., Pope W.H.,
RA Jacobs-Sera D., Hatfull G.F.;
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; MK977705; QDF15365.1; -; Genomic_DNA.
DR Proteomes; UP000319811; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 2.
DR PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000319811};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..269
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 269 AA; 30874 MW; 1592959A492D318B CRC64;
MTFAPDTPYE DLLLDVLENG TDKADRTGTG TRSLFGAQLR YNLAEGFPLI TTKKVHFKSI
AYELLWFLRG DTNVQWLNDH GVTIWDEWAD AGGNLGPVYG AQWRTWYDGE NQLDLDQISY
AMKLLREDPD SRRNIVSAWN VADLPEMALH PCHIMFQLYV ADGRLSLQVY QRSADLFLGV
PFNIASYALL AHMFAQQAGL RVGELIWTGG DCHIYDNHVD QVREQLRRRP RAYPRLRLHM
RDSIFAYRYE DIEIVGYDPH PAIKAPVAV
//
