ID   A0A4Y7KVY3_PAPSO        Unreviewed;       932 AA.
AC   A0A4Y7KVY3;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Insulin-degrading enzyme-like 1, peroxisomal {ECO:0008006|Google:ProtNLM};
GN   ORFNames=C5167_001669 {ECO:0000313|EMBL:RZC77504.1};
OS   Papaver somniferum (Opium poppy).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Ranunculales; Papaveraceae; Papaveroideae;
OC   Papaver.
OX   NCBI_TaxID=3469 {ECO:0000313|EMBL:RZC77504.1, ECO:0000313|Proteomes:UP000316621};
RN   [1] {ECO:0000313|EMBL:RZC77504.1, ECO:0000313|Proteomes:UP000316621}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. HN1 {ECO:0000313|Proteomes:UP000316621};
RC   TISSUE=Leaves {ECO:0000313|EMBL:RZC77504.1};
RX   PubMed=30166436; DOI=.1126/science.aat4096;
RA   Guo L., Winzer T., Yang X., Li Y., Ning Z., He Z., Teodor R., Lu Y.,
RA   Bowser T.A., Graham I.A., Ye K.;
RT   "The opium poppy genome and morphinan production.";
RL   Science 362:343-347(2018).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   EMBL; CM010723; RZC77504.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Y7KVY3; -.
DR   STRING; 3469.A0A4Y7KVY3; -.
DR   EnsemblPlants; RZC77504; RZC77504; C5167_001669.
DR   Gramene; RZC77504; RZC77504; C5167_001669.
DR   OMA; WIFDEMK; -.
DR   Proteomes; UP000316621; Chromosome 9.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000316621};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          31..165
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          193..369
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          432..621
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          626..809
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   932 AA;  106661 MW;  B2F742078DFECDCE CRC64;
     MAVGITDGAI TKPHTDNREY RRIVLPNSLE VLLISDPETD KCAASMSVGV GYFSDPEGLE
     GLAHFLEHML FYASEKYPVE DSYSKYITEH GGSTNAYTST EHTNYFFDVN TDSFEEALDR
     FSQFFIKPLM SADATTREIK AVDSENQKNL LSDAWRMTQL QQHLSTEGHP YHKFGTGNWD
     TLEVRPKQKG LDTRNELIKF YEEHYSSNIM RLVIYGKKNL DDLQSLVDQK FKEIRNTDKN
     CFHFSGQPCK AEHLQILVKA IPIKQGHKLK IVWPITPSIL HYKEAPCRYL GHLIGHEGEG
     SLFCILKTLG WATGLSAGED DSSNDYAFFK VNIDLTDSGN EHMEDIVGLL FKYVILLQQS
     GVSKWIFDEL SAFCETVFRY QDKTRPINYV AKVSSNMQLY PAKDWLVGSS LPSNFSSSII
     QMILDELTPA NQWISAAPNQ NLHLPAPNVF IPTDLSIKDL TEKVKFPVLL RKSSYSRLWY
     KPDTMFFTPK AYVKIDFNCP YTSHTPEAVV LTDVFTRLVM DYLNEYAYDA QVAGVYYGIN
     STDTGFQVIV TGYNHKMRIL VDKIIEQIQE FKVKPERFAV IKETVLKEYQ NYKFQQPYQQ
     AMYYCSLILA DASWPWTEQL EVIPHLEADD LAKFSTMLLS KAFVECYAAG NIEPKEAEEM
     VIHIEDIFFK GLQPIARPLF PSEHLTNRIV KLESGISHFY PAEVLNPSDE NSALVHYIQV
     HQDSTMLNVK LQLFALIAKQ PVFHQLRSVE QLGYITVLMQ RNDSGIRGLQ FIVQSTAKDP
     GQIDLRVESF LKEFESKLYE MPADEFMSNV NALIDMKLEK HKNLSEETSF FWREIFDGTL
     KFDRREIEIA ALKNLRQQEL IDFFDEYIKV GAPAKKTLSV QVYGGSHSSN YEASTKEISS
     HPQSVLIEDI FSFRRSQPLY GSFKGGSGLM KL
//