ID A0A4Y7QF19_9AGAM Unreviewed; 362 AA.
AC A0A4Y7QF19;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Peroxidase {ECO:0000256|RuleBase:RU363051};
DE EC=1.11.1.- {ECO:0000256|RuleBase:RU363051};
GN ORFNames=BD410DRAFT_895652 {ECO:0000313|EMBL:TDL26244.1};
OS Rickenella mellea.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Hymenochaetales; Rickenellaceae; Rickenella.
OX NCBI_TaxID=50990 {ECO:0000313|EMBL:TDL26244.1, ECO:0000313|Proteomes:UP000294933};
RN [1] {ECO:0000313|EMBL:TDL26244.1, ECO:0000313|Proteomes:UP000294933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZMC22713 {ECO:0000313|EMBL:TDL26244.1,
RC ECO:0000313|Proteomes:UP000294933};
RG DOE Joint Genome Institute;
RA Krizsan K., Almasi E., Merenyi Z., Sahu N., Viragh M., Koszo T., Mondo S.,
RA Kiss B., Balint B., Kues U., Barry K., Hegedus J.C., Henrissat B.,
RA Johnson J., Lipzen A., Ohm R., Nagy I., Pangilinan J., Yan J., Xiong Y.,
RA Grigoriev I.V., Hibbett D.S., Nagy L.G.;
RT "A transcriptomic atlas of mushroom development highlights an independent
RT origin of complex multicellularity.";
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|PIRSR:PIRSR601621-2,
CC ECO:0000256|RuleBase:RU363051};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|PIRSR:PIRSR601621-
CC 2, ECO:0000256|RuleBase:RU363051};
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|PIRSR:PIRSR601621-2};
CC Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
CC {ECO:0000256|PIRSR:PIRSR601621-2};
CC -!- SIMILARITY: Belongs to the peroxidase family. Ligninase subfamily.
CC {ECO:0000256|ARBA:ARBA00006089, ECO:0000256|RuleBase:RU363051}.
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DR EMBL; ML170162; TDL26244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Y7QF19; -.
DR STRING; 50990.A0A4Y7QF19; -.
DR VEuPathDB; FungiDB:BD410DRAFT_895652; -.
DR Proteomes; UP000294933; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:InterPro.
DR CDD; cd00692; ligninase; 1.
DR Gene3D; 1.10.520.10; -; 1.
DR Gene3D; 1.10.420.10; Peroxidase, domain 2; 1.
DR InterPro; IPR044831; Ccp1-like.
DR InterPro; IPR002016; Haem_peroxidase.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR001621; Ligninase.
DR InterPro; IPR024589; Ligninase_C.
DR InterPro; IPR019793; Peroxidases_heam-ligand_BS.
DR PANTHER; PTHR31356:SF8; L-ASCORBATE PEROXIDASE 6-RELATED; 1.
DR PANTHER; PTHR31356; THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF00141; peroxidase; 1.
DR Pfam; PF11895; Peroxidase_ext; 1.
DR PRINTS; PR00462; LIGNINASE.
DR PRINTS; PR00458; PEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS00435; PEROXIDASE_1; 1.
DR PROSITE; PS50873; PEROXIDASE_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|PIRSR:PIRSR601621-2, ECO:0000256|RuleBase:RU363051};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601621-4};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heme {ECO:0000256|PIRSR:PIRSR601621-2};
KW Iron {ECO:0000256|PIRSR:PIRSR601621-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601621-2,
KW ECO:0000256|RuleBase:RU363051};
KW Oxidoreductase {ECO:0000256|RuleBase:RU363051};
KW Peroxidase {ECO:0000256|RuleBase:RU363051, ECO:0000313|EMBL:TDL26244.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000294933};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU363051}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU363051"
FT CHAIN 23..362
FT /note="Peroxidase"
FT /evidence="ECO:0000256|RuleBase:RU363051"
FT /id="PRO_5021493898"
FT DOMAIN 71..341
FT /note="Plant heme peroxidase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50873"
FT ACT_SITE 76
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-1"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 90
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 92
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 94
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 199
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 200
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 217
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 219
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT BINDING 224
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-2"
FT SITE 72
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-3"
FT DISULFID 44..308
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-4"
FT DISULFID 63..144
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-4"
FT DISULFID 272..337
FT /evidence="ECO:0000256|PIRSR:PIRSR601621-4"
SQ SEQUENCE 362 AA; 37600 MW; 28845353D3FA0593 CRC64;
MAIKSLLAST ITVVALFNAS QAGVINKRKT ACAGTVHQAA NPACCTWFEV LDDLQSNVLF
SECGEASHTA LRMVFHDAIG FSNTQQFGGG ADGSMIMFGD AELAFAANNG LDEIAGDLKT
VADAHGKTYG DIIQLAGAVG VANCAGAPRL KFLAGRPNAT APAPDGTVPD PFQPVDTILA
RMSDAGFSPD ELVALLASHT IAAADKVDVT IPGTPFDSTA DTFDTQFFIE TQLKGVGFPG
TGANQGEVES PLVGEMRLQS DFALARDSRT ACTWQSFVTD HALMNQRFSD AMDKLAVLGQ
NTQGFLDCSE VIPHPHSLKV IPHLPAGKTS ADVEPACAAT PFPDLPTAPG AATTVKPVPP
GS
//
