ID A0A4Z1SRH4_GIAMU Unreviewed; 451 AA.
AC A0A4Z1SRH4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Cathepsin L {ECO:0000313|EMBL:TNJ28492.1};
GN ORFNames=GMRT_12624 {ECO:0000313|EMBL:TNJ28492.1};
OS Giardia muris.
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5742 {ECO:0000313|EMBL:TNJ28492.1, ECO:0000313|Proteomes:UP000315496};
RN [1] {ECO:0000313|EMBL:TNJ28492.1, ECO:0000313|Proteomes:UP000315496}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Roberts-Thomson {ECO:0000313|EMBL:TNJ28492.1,
RC ECO:0000313|Proteomes:UP000315496};
RA Xu F., Jimenez-Gonzalez A., Einarsson E., Astvaldsson A., Peirasmaki D.,
RA Eckmann L., Andersson J.O., Svard S.G., Jerlstrom-Hultqvist J.;
RT "The compact genome of Giardia muris reveals important steps in the
RT evolution of intestinal protozoan parasites.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TNJ28492.1}.
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DR EMBL; VDLU01000002; TNJ28492.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A4Z1SRH4; -.
DR VEuPathDB; GiardiaDB:GMRT_12624; -.
DR Proteomes; UP000315496; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000315496};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 403..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..328
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 451 AA; 49890 MW; C72DAEE1AEB8AEFF CRC64;
MFLAIIALVV GRYIPLSLEN VTIVSTKGLI RQAARLFYNL HERYNDMHEC QSVYLLEDPL
GRLANIPASF DLREVGLQSP VKDQGRCGSC WAFGTSAAAE AVIMASRSNY TGTPVEPFFG
GVLTNVSEQF ILNSSKFGVN NFCEGGNFVY ALFDLAHGHY DTLEVAEHFP YESASITQNP
KEIVRPTPLL PAKAYLNPFL TASVSSLCKA NVVHIFQDAR KSFDAKTISV IKSYIARGIP
VVGAMYTQSN GLLGSDAFSR YSGGVFHQEC VTYGADHQIV FVGYGKHKGV DVWVIRNSWG
ESWGIYGYAY IPIGRNTMCS EHTAYAAIPQ AHDSLRTRDF NFILVDRDSI LALGKEYVRP
DEYFDYYDSR LTRGENGLDP DDAPYDNDGL DGKNAPMDKN NALYISLITI GVIMGVALLA
VLIAFCVIRA RFHRLARLQR APTGTLYNIT G
//
