ID   A0A4Z2D084_SCHJA        Unreviewed;      1120 AA.
AC   A0A4Z2D084;
DT   18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2019, sequence version 1.
DT   22-FEB-2023, entry version 11.
DE   SubName: Full=Huntington interacting protein related 1 isoform 1 {ECO:0000313|EMBL:TNN09874.1};
GN   ORFNames=EWB00_005902 {ECO:0000313|EMBL:TNN09874.1};
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182 {ECO:0000313|EMBL:TNN09874.1, ECO:0000313|Proteomes:UP000311919};
RN   [1] {ECO:0000313|EMBL:TNN09874.1, ECO:0000313|Proteomes:UP000311919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HuSjv2 {ECO:0000313|EMBL:TNN09874.1};
RC   TISSUE=Worms {ECO:0000313|EMBL:TNN09874.1};
RA   Hu W., Luo F., Yin M., Mo X., Sun C., Wu Q., Zhu B., Xiang M., Wang J.,
RA   Wang Y., Zhang T., Xu B., Zheng H., Feng Z.;
RT   "An improved genome assembly of the fluke Schistosoma japonicum.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TNN09874.1}.
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DR   EMBL; SKCS01000385; TNN09874.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A4Z2D084; -.
DR   STRING; 6182.A0A4Z2D084; -.
DR   Proteomes; UP000311919; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000311919}.
FT   DOMAIN          15..143
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   DOMAIN          865..1104
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          297..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          428..483
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          523..550
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          576..652
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1120 AA;  127993 MW;  DEE1DEBEB73D5A66 CRC64;
     MPLPNFDTIK SLAVGKDNPN RQQVVHILKA ITDHEVPPKQ KHIRGIILAT FSGKSSSFLY
     DTALKLAIYT NPVVCWKFLY IIHKLFRDGH RECVNDGLRH ATRVYQLKSA WSNHATKCGY
     PIVDFCQLII RKLRLHRKYG VLPGSLELNP NELKNVLSAQ VDHLFQFSVD LMDMMEETLR
     FKDVVLLSVE GIHAPSFTPP GQCKLIPLIQ CIQDVAALYE LSVQLIFKLH ELLGNGTMSG
     HRDRFKDLHT SVKKFFENVF HMQYFRSFVH IPSISQNPPN FCIQSELNEH TTLRVTMNET
     PSLPSPPQSP PTTVTPADGN NGQHSGDEED SFELADVPKV ISHNYQTESL TEKQALIKLG
     PENIDTNDKT VISLNEGSSA SDNHHQICNN SINSNNNMKM NRNPFLNNSI QTNSHELSPY
     QAHITDEKHE VLIEVELLKS EIERLKTEHH EQSYSLLSRI QILEDEIKEL VQYKSNHEEQ
     QVNYETKLSE KVCQAQIFEE KFMKLKEVYG KLREEHVILL KNYGNVQQNL QQETQKNEDL
     EKMIENLRHQ EMLLPSDNVE CLPTSENEAK VPVANCLELQ NQLNDYRSKL DSANIEKDQL
     VAELFLLKEE CCSMREKFFE SQQFIKDYEL KISKLTNELQ ELNDQLHRGN LSVGKSSNVC
     NGNTSNIVSD NDDGGDGHIS WNNEPKQSLL TTTIEQLLSE LQCSQSVAQP TDLMEVYIHF
     SPKYFSNYLL QIINHFNLFE SAITSYLSND VKGLIQTSFH IGQLNSQLSL LSLYSRSIHQ
     SNTTFSFSND YLHGFDLIQK QFMQLLNILQ QVDSTHQDDE NANDNISHKD NYFNQIKEHL
     CIIYHQLNFM LNEVTNLSNC WSNNVNNGDT KTSVDVIQKE MEATFEAITI AEQKFQDLIA
     ESKSHSTSNE NLQVNSLILD CCSELLLCVG ELVKQSKIIQ QEFKDSSTSI EFYKPYNRWT
     DGLLSAAKFV GAGANVMVEI ANSIVCGKGV KLERLIVISQ EIAASTTQLV YATRVKTNSQ
     PEMFNKLQVT SKEVCKCTGN LIACVKKAIE AKHVEGTMSN IFFKMYAYCV VVFDEYIKEI
     RSCRNLSESH QVFWCIWLSV HRKTYRPLVR LPHTIEGSDL
//