ID A0A504WV47_FASGI Unreviewed; 2595 AA.
AC A0A504WV47;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Protein flightless-1 {ECO:0000313|EMBL:TPP39694.1};
GN ORFNames=FGIG_06914 {ECO:0000313|EMBL:TPP39694.1};
OS Fasciola gigantica (Giant liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Fasciolidae;
OC Fasciola.
OX NCBI_TaxID=46835 {ECO:0000313|EMBL:TPP39694.1, ECO:0000313|Proteomes:UP000316759};
RN [1] {ECO:0000313|EMBL:TPP39694.1, ECO:0000313|Proteomes:UP000316759}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Uganda_cow_1 {ECO:0000313|EMBL:TPP39694.1};
RA Choi Y.-J.;
RT "Annotation for the trematode Fasciola gigantica.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TPP39694.1}.
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DR EMBL; SUNJ01015903; TPP39694.1; -; Genomic_DNA.
DR STRING; 46835.A0A504WV47; -.
DR Proteomes; UP000316759; Unassembled WGS sequence.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd11280; gelsolin_like; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.20.10; Severin; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR028119; Snapin/Pallidin/Snn1.
DR InterPro; IPR007122; Villin/Gelsolin.
DR PANTHER; PTHR11977:SF139; PROTEIN FLIGHTLESS-1 HOMOLOG; 1.
DR PANTHER; PTHR11977; VILLIN; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00626; Gelsolin; 3.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14712; Snapin_Pallidin; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 4.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 6.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000316759};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 729..860
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 869..1037
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 278..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1050..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2270..2294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1717..1744
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 287..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..934
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2595 AA; 294315 MW; 651C9AB028B76E08 CRC64;
MSPSYANNWS VHQLSFLFGF QSIETRSSMP TVPLNEIKVE EIAELLRTKY AIFTGGHDRE
FRSLVIFPDY QTENLAEESF VLLLQYLSTM NSTHSSVHAF VILIDRRTGD WKSVKTIVSR
LNTTFPASID HIYVIKPQGF VQRFFVEKTV SWIREESRFP ITFVDKLEEL SPFIDSVHLP
TDMGGQLCFN IENWLRDRAQ FEQFRDRVTL LCERAQQLLD QFGQPSPPVV GVQLQVYLAN
PSYSPSLMVT WKNQRRKFLD AIDRCEADGL KLRQTLRDGP YYPGESSPVT ANDQTGTSNW
THADENFDLP VDRVFHVINL EHTLVKLTET RSVFNQAWRQ FTKRAGIIKL MADIEQRFVE
LEPLAGMWEN LLESASDYFQ SSRSIGRQLT NLSTRQPTSA SLLTSVSRSS SFDGSCFGLI
ADPSESTTED MYLEDLRAVV NRLTEADQLG AGLLPDLLAL SKTTTWVVDY IRMEKSNISL
DSETSGIEAL TRFTFILDND SDPGELDSPS SVGTVSSMSS LKLPTIQLPR NAERWASMFR
RLLMLAQTKL PNSADQLNRL LQLYSEMNKA RSWIRRGVEL ITPVISNDSF NSWSLEHCHQ
KLSELRAYYA LREEGNLRGV TDPKFFHQRF SDIITMDLRI SSNVSDSRSR HSSPSHSFPA
ASGSDVLVVC KSSEAVTSPA DRFRLAWEEL VETERSYVLW LQKDNTECGP LESGSGARSF
PGTSPIPPFM RENQAWLLAP RIIDLYSTYC SSHDSAVQVA VHLERDRFYS AWINACNERL
YSREQSAAGS HTTHTNDASD SVVRPLLKFS SRLITPVQRF QRYHLLIERL LRLSLTEADK
QDLSEAHQTM LQVCETVNLT MRFRGLSIRP SELGRLLLHA DFTVSRDDMR MISGKQRHVF
LFTNVMLLTK FRPSATTSSP LLSSNSSVPN PLSSDFTPDG KERISSIASF TGPTSHLLVS
NIANLAKTHI LMSSVSGNST GSLSSNELAQ IGLTPSVRAD RRRFAVWTAN RAQTYIFHAS
DSTIRDRWVH SVNDLLMAQL RRLRDEAMQR HGPNSNRFSS PQRKVHTGNH TDRSCSLPLP
SSLHFAKVTA TSIRDSSGSF YMILESEQSS LRTLLLTPSS ERPATTHQSI DNSVADISNS
DLTIDSDKLS SIEQRREGEQ ELADGLLTVI KPNLERLDQA AFNLDGSQTE LRNQLNSLIE
ILNRVESIHQ CPVDLEPYVY RLGIYKTRIL RVHSLLQRLQ AVIQYLRGLD LTGVHFGPDD
PVQAAMDGHS TTRGSSRSST TTTLWPKTDV LASMCRLQWL KLRDTGLTED QLPAELAKLA
QLENLSISRN ALTHLSALED WSTLLPSLRS LNCRKNNLTD VDAIPVSIFE CANLQVVDFS
CNRLTSVPRG IEKAKGLLVL NLSRNAITSV PSELFVQCTD LMLLDLSDNQ LDSLPAQLRR
CGSLQQLILS NNPLRLAHLR AVSSLKQLEV LHLASAQRTL DNIPTDLDKL ERLIELDLSD
NALTRVPEPV LALRSLRKLN LARNQINDLS QVTDNWPKLE YLNVGYNQLA QLPSGMTRLV
KLRKLYMNNN RLAFAGIPSG IGKLQDLEIF DASYNELENI PESLCRCGRL KRLNLNSNRL
LTLPDAIHYL RETLETFDVD NNPQLKFPPK PPEMQKGAGL AYYNIDFSLD AQLRQICGKP
PESADASRHA KDTASRLRRL CRRRGDGAGE GDSRCVLEGM QRIAREKEEL LRKREEEAEE
ESKMIAVKRW QDQLNKPHLD YSGIFDEDTG SVEGLEMWEI DEFYPKRVED DVAHGRLLDG
DCYIVLQTKR TPNQTLDWVI YYWIGLNASR DKQTCAAVHA VNLRNFLGAE GRTFREEQNE
ESEEFLALFG GNLMILGGAH GETGFFHVEE QNVNVKLYRL FGLEKRLLIV SMPLTPLSLD
PKFCYLIDGH SQLFLWLGSE SRLMVRTKGR LLAEKISVRE RRGEATIHLE PQGRESNTFW
AVIMGVWVPP ALPNLVSISE SENGSGGVTA NASVTDGSQV TKTHPLPPEV DQPQNVPRDF
IPVDWRLPQP ILYDVELPLG QLSKRVLDPK HVYLLDSGGE LFVWMGEKST RFLRFAGCKL
AQELTDLMPR GCFGGAESQL AVVLFAATDL SSAARLTFVR PAPQICSQGA ENQIFRAQFH
DWEEAIAVDF TRTVESVAKR GVDMNAILEK YKPATDLRVL LTPRERALEW NEAMQLMSDW
NEELVEPIGP DLIPNTALQQ FIMIEGKWVP VEQQWFGHFF SQDSYIDFDD EQSSADPEGG
ANTGEVDEPS EEERTKTVVY FWQGREASEL NWLTFNFSLR KDMETRLSTN PNENGRPLKV
EFKRVRQQQE DLVFLAHFQR QLIIHSGHYR DRLSSARQDK VQMYYMRANG NAISTRSIEV
PPSSSFMNTY FCYIVKVPGI IFAPDRNDFK HQPPPLVWLW IGKHAHPDDR ELLEKIGKRI
YKDPDTRFEI LYEATENELF WKCVGNKRQV DQSADFLQYG RLFRLSNDQG YFCASEKCSD
FCQDDLADDD VMMLDTGNQI SSPSLFFLVC LLLTRVCKWS SMLYVREHQN RVQLSVILVS
VDNIEDQFHG TLDLI
//
