ID A0A507CFH1_9FUNG Unreviewed; 598 AA.
AC A0A507CFH1;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Protein kintoun {ECO:0000256|HAMAP-Rule:MF_03069};
DE AltName: Full=Dynein assembly factor 2, axonemal homolog {ECO:0000256|HAMAP-Rule:MF_03069};
GN ORFNames=SmJEL517_g01190 {ECO:0000313|EMBL:TPX36674.1};
OS Synchytrium microbalum.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Synchytriales;
OC Synchytriaceae; Synchytrium.
OX NCBI_TaxID=1806994 {ECO:0000313|EMBL:TPX36674.1, ECO:0000313|Proteomes:UP000319731};
RN [1] {ECO:0000313|EMBL:TPX36674.1, ECO:0000313|Proteomes:UP000319731}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEL517 {ECO:0000313|EMBL:TPX36674.1,
RC ECO:0000313|Proteomes:UP000319731};
RX PubMed=31209237; DOI=.1038/s41598-019-45128-9;
RA van de Vossenberg B.T.L.H., Warris S., Nguyen H.D.T.,
RA van Gent-Pelzer M.P.E., Joly D.L., van de Geest H.C., Bonants P.J.M.,
RA Smith D.S., Levesque C.A., van der Lee T.A.J.;
RT "Comparative genomics of chytrid fungi reveal insights into the obligate
RT biotrophic and pathogenic lifestyle of Synchytrium endobioticum.";
RL Sci. Rep. 9:8672-8672(2019).
CC -!- FUNCTION: Required for cytoplasmic pre-assembly of axonemal dyneins,
CC thereby playing a central role in motility in cilia and flagella.
CC Involved in pre-assembly of dynein arm complexes in the cytoplasm
CC before intraflagellar transport loads them for the ciliary compartment.
CC {ECO:0000256|HAMAP-Rule:MF_03069}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03069}.
CC Dynein axonemal particle {ECO:0000256|ARBA:ARBA00024190}.
CC -!- SIMILARITY: Belongs to the PIH1 family. Kintoun subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_03069}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TPX36674.1}.
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DR EMBL; QEAO01000004; TPX36674.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A507CFH1; -.
DR STRING; 1806994.A0A507CFH1; -.
DR EnsemblFungi; TPX36674; TPX36674; SmJEL517_g01190.
DR OrthoDB; 5405608at2759; -.
DR Proteomes; UP000319731; Unassembled WGS sequence.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0060285; P:cilium-dependent cell motility; IEA:UniProtKB-UniRule.
DR CDD; cd00298; ACD_sHsps_p23-like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR HAMAP; MF_03069; Kintoun; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR034727; Kintoun.
DR InterPro; IPR012981; PIH1_N.
DR InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR PANTHER; PTHR22997:SF3; PROTEIN KINTOUN; 1.
DR PANTHER; PTHR22997; UNCHARACTERIZED; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF08190; PIH1; 1.
DR Pfam; PF18201; PIH1_CS; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03069};
KW Reference proteome {ECO:0000313|Proteomes:UP000319731}.
FT DOMAIN 81..219
FT /note="PIH1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08190"
FT DOMAIN 286..383
FT /note="PIH1D1/2/3 CS-like"
FT /evidence="ECO:0000259|Pfam:PF18201"
FT DOMAIN 444..515
FT /note="CS"
FT /evidence="ECO:0000259|Pfam:PF04969"
SQ SEQUENCE 598 AA; 66735 MW; DA04EEA26725B257 CRC64;
MKRKIRESVM YSPSNIKRIQ SITIVNENDK DQIEKYIMAA GAAREKRFEE LNMTDEELKK
ISTSFQDEEF RKLFSDYVNE LSDPKNRELY EREIAQLEAE QGNKVRFVKP TEGHVLKTKF
QKPPSNMANI DKVFINMCTS PEISKAKAKT KSVNGKKGQS WSIPYSLSSP REDVDHANAP
CLVYDFVMHP DTYRMGRNNP AFDKMLVDTA LEGIETKFDG VPTATVIRET DPSLKATAGE
TSLDYIKNMA QEQQKQAVIP TEKSTSSLIQ ELDEPHVASA KPVVVETPKY EILHRGSIDY
SKFTNERERR DGARPESLVV RIELPRVVSG SELNVDTNET TFDLSVPQKY LLHIALPFPV
DHERGQAKFD KSHRRLTVTL PVLPPPLISV AAEQTTIPIP EIVNLDDAVK ENTGEELPAT
EFETESTPLI QQITKPRLPA IKLDQDETSV SIIMPVVDLD ESTISMNFLP LQVSVAFSTK
DGTSYALLAK VPSSILPKGC NLNIDGDQVV VHCQKWAREL WESVDVVDVD GGVSVVRFES
LKSVNVSAAA SVKSEPAVAA TPVEKVETPK VPEKPATVEK KPIVIPTLLN SHVFDLDL
//
