ID A0A507FQF8_9FUNG Unreviewed; 1094 AA.
AC A0A507FQF8;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN ORFNames=CcCBS67573_g00805 {ECO:0000313|EMBL:TPX77940.1};
OS Chytriomyces confervae.
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Chytridiales;
OC Chytriomycetaceae; Chytriomyces.
OX NCBI_TaxID=246404 {ECO:0000313|EMBL:TPX77940.1, ECO:0000313|Proteomes:UP000320333};
RN [1] {ECO:0000313|EMBL:TPX77940.1, ECO:0000313|Proteomes:UP000320333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 675.73 {ECO:0000313|EMBL:TPX77940.1,
RC ECO:0000313|Proteomes:UP000320333};
RX PubMed=31209237; DOI=.1038/s41598-019-45128-9;
RA van de Vossenberg B.T.L.H., Warris S., Nguyen H.D.T.,
RA van Gent-Pelzer M.P.E., Joly D.L., van de Geest H.C., Bonants P.J.M.,
RA Smith D.S., Levesque C.A., van der Lee T.A.J.;
RT "Comparative genomics of chytrid fungi reveal insights into the obligate
RT biotrophic and pathogenic lifestyle of Synchytrium endobioticum.";
RL Sci. Rep. 9:8672-8672(2019).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TPX77940.1}.
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DR EMBL; QEAP01000012; TPX77940.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A507FQF8; -.
DR STRING; 246404.A0A507FQF8; -.
DR Proteomes; UP000320333; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006271; P:DNA strand elongation involved in DNA replication; IEA:UniProt.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036578};
KW Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000320333}.
FT DOMAIN 358..439
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1002..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1048
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1049..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 117804 MW; E0354E5E33729AE3 CRC64;
MASLPVQHRQ LAPTTDHSTT GSAQLFLESR EAESCKTAGR TVESERIIWT EQYNQIRCDS
LTSRCSATLF LNRKETGTKD DSNTQKEKRE VKSQYFASSG SGSSKKSTDM GDEIDPAAFF
SSSKIHQSQK TATIQKQPRK TISRIAKPDD DDEFKDFDVD LTQIDEVALK ARFIRCCFCV
NFVWFISGFK VSSPLKKHAP VSAPVSAPSP PVVAPSPPVV APSPPVVKRG PSKKRATVFI
DDDDDDDVEM SLAQPLPKPK SPLKLAEVNP SAQEPAKPKP KSPPKHAEVK STVQETVKRK
EVDASSGSKD ETVSAAAPPP SSQPTEASKK ANYMKMLAKK AAGGGGPSAP GSKEIPVGEE
NCLTGLTFVF TGELSSISRD DAQNLVKRYG GRVTGAVSGK TSYLVAGEDS GESKLSKAKS
VKVKIIDEDG FLDVIASSKG KPSSGSSTPS AKAGKKAVGT DVKENKLKES TSSMSSSSFY
GSSSKGKAPA TPTEIRAPKP HSSELWTTKY KPTRYEDVLG NKKNVEKLAI WLKGWSASTV
TPKPSSAKDD PGKSRAILIS GPPGIGKTTA AHLVAKLEGF EIVEFNASDT RSKKAVGDVV
KEMTGSHTLA EYFTRDSKSK PIKRQVLIMD EVDGMSAGDR GGVAELINVI KNTKVPIICI
CNDRQSPKVK SLVNHCFDMR FARPRTTEIE KAIKVIAAKE GLDIKINAME AMVQSTHADI
RQILNMLSTY ALQSSELSFD QSRALSKSSE KNMTMSPWDV TGTLFNRVSF RETSFADKLE
LYFSDFSLIP LMIQENYIKM DPVLAKENGG PNKAQQDIEA LNLLSNAADA IAHADIISSV
QMKTQNWGLL PFHGVTSTIR PAFFTHGSLV NTGSFYGGGY AFPSWLGKNS NQSKNVRLLK
EIQLHMRLHV SADKNEVRQS YLPALAPLIT LPLAKDSSGV EQVIQTMDDY YLTREDWDSI
LDLGLDECSA KALTADIPTA TKTAFTRTYN KANHPKPFMT ASLLSKSRGG GGGMSGVPDL
EEAFENDDEG AGVGDDEDGA GEDADEDDVG ADRLIKKKEK AAPRKSAAGG SGAKGGKRGA
DGGAKASASK KVKK
//
