ID A0A509AMG3_PLABA Unreviewed; 534 AA.
AC A0A509AMG3;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
GN ORFNames=PBANKA_1237900 {ECO:0000313|EMBL:VUC57275.1};
OS Plasmodium berghei (strain Anka).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5823 {ECO:0000313|EMBL:VUC57275.1, ECO:0000313|Proteomes:UP000074855};
RN [1] {ECO:0000313|EMBL:VUC57275.1, ECO:0000313|Proteomes:UP000074855}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ANKA {ECO:0000313|EMBL:VUC57275.1,
RC ECO:0000313|Proteomes:UP000074855};
RX PubMed=25359557; DOI=10.1186/preaccept-1233682211145405;
RA Otto T.D., Bohme U., Jackson A.P., Hunt M., Franke-Fayard B.,
RA Hoeijmakers W.A., Religa A.A., Robertson L., Sanders M., Ogun S.A.,
RA Cunningham D., Erhart A., Billker O., Khan S.M., Stunnenberg H.G.,
RA Langhorne J., Holder A.A., Waters A.P., Newbold C.I., Pain A., Berriman M.,
RA Janse C.J.;
RT "A comprehensive evaluation of rodent malaria parasite genomes and gene
RT expression.";
RL BMC Biol. 12:86-86(2014).
CC -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC mitochondrial processing protease (MPP), which cleaves the
CC mitochondrial sequence off newly imported precursors proteins.
CC {ECO:0000256|ARBA:ARBA00002123}.
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DR EMBL; LK023127; VUC57275.1; -; Genomic_DNA.
DR RefSeq; XP_679923.1; XM_674831.1.
DR AlphaFoldDB; A0A509AMG3; -.
DR STRING; 5823.A0A509AMG3; -.
DR VEuPathDB; PlasmoDB:PBANKA_1237900; -.
DR InParanoid; A0A509AMG3; -.
DR OMA; LKYHHSP; -.
DR OrthoDB; 7099at2759; -.
DR Proteomes; UP000074855; Chromosome 12.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000074855}.
FT DOMAIN 114..261
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 271..454
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 534 AA; 61264 MW; 59F41F79E556BA53 CRC64;
MNTNIQKLKL VLNKTKLGTK SYSHDVSKLK RNPNLEKLYT GDKHDFSKVI FKKEQIEDVI
KEVKFDYYYF NEGKKNKYKD IPLNVSIIKE SDLPPYKPVD EKLNFSILEN DLKIISTNKN
SGVCSIGLYI KCGSRYEEIN DKINEQGMSV MIENMAFHST AHLSHLRAIK SLEKIGANVS
CNAFREHIVY TCECLNEYLP IVINLLIGNV LFPRFLSWEM KNNVNRLNTM RAKLFENNEM
YITELLHNTA WYNNTLGNKL YVSESNIENY TSENLRNFML KHFSPKNMTL VGINVDHNEL
TKWTSRAFQD YVPIPYIKQK EVTPNYTGGF ISVEDKNIKK TNIAIAYETK GGWKTSDMIT
LTVLQTLMGG GGSFSTGGPG KGMYSRLFLN VLNNYNFIES CMAFSTQHSD TGLFGLYFTG
DPANTKDIIN SMALEFHKMN KCTDEELNRA KKSLKSFMWM SLEYKSILME DLARQMMILN
RILSGKQLCD AIDAVTKEDI NRVVSQFLKT KPTVVVYGNI SHSPHYDEIC KMLG
//
