ID A0A509AMU4_PLABA Unreviewed; 823 AA.
AC A0A509AMU4;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Dipeptidyl peptidase 1 {ECO:0000256|ARBA:ARBA00014709};
DE AltName: Full=Cathepsin C {ECO:0000256|ARBA:ARBA00029779};
DE AltName: Full=Cathepsin J {ECO:0000256|ARBA:ARBA00029762};
DE AltName: Full=Dipeptidyl peptidase I {ECO:0000256|ARBA:ARBA00032961};
DE AltName: Full=Dipeptidyl transferase {ECO:0000256|ARBA:ARBA00030778};
GN ORFNames=PBANKA_1002400 {ECO:0000313|EMBL:VUC56022.1};
OS Plasmodium berghei (strain Anka).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5823 {ECO:0000313|EMBL:VUC56022.1, ECO:0000313|Proteomes:UP000074855};
RN [1] {ECO:0000313|EMBL:VUC56022.1, ECO:0000313|Proteomes:UP000074855}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ANKA {ECO:0000313|EMBL:VUC56022.1,
RC ECO:0000313|Proteomes:UP000074855};
RX PubMed=25359557; DOI=10.1186/preaccept-1233682211145405;
RA Otto T.D., Bohme U., Jackson A.P., Hunt M., Franke-Fayard B.,
RA Hoeijmakers W.A., Religa A.A., Robertson L., Sanders M., Ogun S.A.,
RA Cunningham D., Erhart A., Billker O., Khan S.M., Stunnenberg H.G.,
RA Langhorne J., Holder A.A., Waters A.P., Newbold C.I., Pain A., Berriman M.,
RA Janse C.J.;
RT "A comprehensive evaluation of rodent malaria parasite genomes and gene
RT expression.";
RL BMC Biol. 12:86-86(2014).
CC -!- COFACTOR:
CC Name=chloride; Xref=ChEBI:CHEBI:17996;
CC Evidence={ECO:0000256|ARBA:ARBA00001923};
CC -!- SUBUNIT: Tetramer of heterotrimers consisting of exclusion domain,
CC heavy- and light chains. {ECO:0000256|ARBA:ARBA00011610}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; LK023125; VUC56022.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A509AMU4; -.
DR VEuPathDB; PlasmoDB:PBANKA_1002400; -.
DR InParanoid; A0A509AMU4; -.
DR OMA; CDFFNQG; -.
DR OrthoDB; 198334at2759; -.
DR Proteomes; UP000074855; Chromosome 10.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0008239; F:dipeptidyl-peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 2.40.128.80; Cathepsin C, exclusion domain; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR014882; CathepsinC_exc.
DR InterPro; IPR036496; CathepsinC_exc_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF895; CATHEPSIN B; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08773; CathepsinC_exc; 1.
DR Pfam; PF00112; Peptidase_C1; 3.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF75001; Dipeptidyl peptidase I (cathepsin C), exclusion domain; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:VUC56022.1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000313|EMBL:VUC56022.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000313|EMBL:VUC56022.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000074855};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..823
FT /note="Dipeptidyl peptidase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021446095"
FT DOMAIN 405..811
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 823 AA; 97128 MW; BA388ADAB3A3F396 CRC64;
MILIPLFFYI FLNYIKCDIP VHCLSRHVEG LWEIKLGLLK NKQFEKENNE YSKIDNRVDK
NYYDYECGYK RPDDSKYHDA LDPENVKKRF EIKDKKIIAF NKDRTINIIE NGKSVPEYSG
YWRIVYDEGL HIEIYNSKNK NKEIYFSFFK FVKNGEVSYS YCSNLVMGVV SMYHLNENTD
ITKSNANIVN NSRINNCNDK ITRNSMVDDI NIDSSKCMNK FEENGKENNS SINNRITKKE
LGEKNIIFRY AYALYGVLKN SYLNILNNTV ELKENESVAL NDVEKLYGNN NDVETLIDHY
NDNFIDFKTM SMKRYCWSGK KLDKNSDKAT NKISNMLSPL DVNADTQNHN YYINLIGDEK
NKGVLTNNKG KKRKINNIQG VINNPPTKKI KENSLFNMYS NRDIALKNFD WSDENDVKER
FNGNSIRIFD EAIDQKECGS CYANSASRII NSRIRIKYNY IKKIDSLSFS NEQLLICDFF
NQGCNGGYIY LSLKYAYENY LYTNKCFERY ENLYINKDDK NNSLCDRFDT FKIFLKKKEK
NIYINNYHEK MEQKNEHIKI YNNFGNTHDN SDNRNDSNIH KKLVKGENIN YIYRLVDSGK
QGKGNVSDDY LNEDYILVDK TMYERGKFKL DELDSCDTKI KVTKYEYLDI ENEENLKKYI
YYNGPVAAAI EPSKSFIKYK KGILTGNFIK MQDGDKSNAY IWNKVDHAVV IVGWGEDTIE
NLIKKKMKIN NSKKITHSYD EYKSKNNDNL DENIYDKHIN SYVKNTKEKN KVIKYWKVLN
SWGTKWGYNG YFYILRDENY FNIRSYLLIC DVNLFVKNKN VKL
//