ID A0A509APT6_PLABA Unreviewed; 240 AA.
AC A0A509APT6;
DT 18-SEP-2019, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=tRNA(adenine(34)) deaminase {ECO:0000256|ARBA:ARBA00012740};
DE EC=3.5.4.33 {ECO:0000256|ARBA:ARBA00012740};
GN ORFNames=PBANKA_1362200 {ECO:0000313|EMBL:VUC58009.1};
OS Plasmodium berghei (strain Anka).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX NCBI_TaxID=5823 {ECO:0000313|EMBL:VUC58009.1, ECO:0000313|Proteomes:UP000074855};
RN [1] {ECO:0000313|EMBL:VUC58009.1, ECO:0000313|Proteomes:UP000074855}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ANKA {ECO:0000313|EMBL:VUC58009.1,
RC ECO:0000313|Proteomes:UP000074855};
RX PubMed=25359557; DOI=10.1186/preaccept-1233682211145405;
RA Otto T.D., Bohme U., Jackson A.P., Hunt M., Franke-Fayard B.,
RA Hoeijmakers W.A., Religa A.A., Robertson L., Sanders M., Ogun S.A.,
RA Cunningham D., Erhart A., Billker O., Khan S.M., Stunnenberg H.G.,
RA Langhorne J., Holder A.A., Waters A.P., Newbold C.I., Pain A., Berriman M.,
RA Janse C.J.;
RT "A comprehensive evaluation of rodent malaria parasite genomes and gene
RT expression.";
RL BMC Biol. 12:86-86(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC Evidence={ECO:0000256|ARBA:ARBA00001103};
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DR EMBL; LK023128; VUC58009.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A509APT6; -.
DR STRING; 5823.A0A509APT6; -.
DR VEuPathDB; PlasmoDB:PBANKA_1362200; -.
DR InParanoid; A0A509APT6; -.
DR OMA; IVFGCGN; -.
DR OrthoDB; 3626893at2759; -.
DR Proteomes; UP000074855; Chromosome 13.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:InterPro.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR028883; tRNA_aden_deaminase.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11079:SF149; TRNA-SPECIFIC ADENOSINE DEAMINASE 2; 1.
DR Pfam; PF00383; dCMP_cyt_deam_1; 1.
DR Pfam; PF14437; MafB19-deam; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000074855};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 8..73
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|Pfam:PF00383"
SQ SEQUENCE 240 AA; 27815 MW; 507F02C94B5A56EC CRC64;
MVELSNEEAI RFLKQALNEG EKSLKVETKE MPIFCLLINE EKQIISSSYN CTNEAKNGCR
HCEIIAIDKY IYGENYEKMK NKNLIKCFNN NNNSINKSLS NYFANLENSD KEFWDSKENT
NCTKDDSINF EEIQKEITEK IQKLKKFTIV VTCEPCIMCV YALKLVGIQH IYFCCLNERF
GGCGSVLSLH ELYENMNIHY IECNDCTNRS INLMKLFYKA GNPSAPDEKR KRPLAEVSLE
//
