ID A0A512U7S5_9ASCO Unreviewed; 1033 AA.
AC A0A512U7S5;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 13-SEP-2023, entry version 14.
DE RecName: Full=I/LWEQ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=JCM33374_g561 {ECO:0000313|EMBL:GEQ66898.1};
OS Metschnikowia sp. JCM 33374.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Metschnikowia.
OX NCBI_TaxID=2562755 {ECO:0000313|EMBL:GEQ66898.1, ECO:0000313|Proteomes:UP000319698};
RN [1] {ECO:0000313|EMBL:GEQ66898.1, ECO:0000313|Proteomes:UP000319698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 33374 {ECO:0000313|EMBL:GEQ66898.1,
RC ECO:0000313|Proteomes:UP000319698};
RA Hirao A.S., Imai R., Endoh R., Ohkuma M., Degawa Y.;
RT "Draft genome sequence of a novel Metschnikowia sp. strain JCM 33374, a
RT nectar yeast isolated from a bumblebee.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GEQ66898.1}.
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DR EMBL; BIMT01000002; GEQ66898.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A512U7S5; -.
DR STRING; 2562755.A0A512U7S5; -.
DR Proteomes; UP000319698; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR CDD; cd17007; ANTH_N_Sla2p; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00273; ENTH; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50942; ENTH; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000319698}.
FT DOMAIN 1..127
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT DOMAIN 788..1027
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 268..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 309..351
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 398..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 482..604
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1033 AA; 117019 MW; ED151ABA470919B0 CRC64;
MSRAEVDLQI SVRKACNTEE VPPKRKHVRA CIVYTWDHKN SRAFWNAVKI QPLQSSEVQL
FKALIMIHKV LQEGHPNTLK DGYRNRDFLY SLSTVFPSTS NYGLLINQYD RFLLQKLDFH
RSNPGFNGIF EYEEYISLRT VNDPNEGYES ILQLMDLQDL INDLQKHIFA TVHQSPNNLC
KVSALVPLIS ESYGVYKFLV SMLRAMFQQL GDDDALSALF DRFNSQHFVL REFYTDCQSI
KFLTSLITIP RIAASVPNLR ISDESQRLTT VSSTQNGSEA SQSAQATGNF DNAENTPQVN
SFELQNTAAF DQQRQLEQQQ YELEAQRQQQ LQEQIRRQQL FEQQMKEQEQ KRLQDQQILT
EQQMLRQQQT QMNQSRVSEL EQDLLNFKAQ FDNDQALLQQ YDSRVKSMET ELININETAA
QQIFTKDEQL KLANEQISNW SKKYESLAKL YSQLRSEHLN LLAKFKKIQQ KISSAQESIL
KKEKYEKDLK SKNLELADII RERDRARLDL DRLKASKDSE IEHLQTQIRE ASAQASEFSS
AKTMDLTSKI SKYEADVEKL KTDLDDREKL LASMGSVSSL KESLKEKEMD LEITQESLDS
ALRELSIARK SSNSQYLANI LDVILANSVK RVQDSKYEFL SPMQAGNSNA TPEYLLSFLE
LCSDTATNFA QALNELVVEG NENLDQSPYP SIILASSELT SALHDLMLNS KGLSKNITAD
EGDRLTSEIT NALSGAESFF SNLTSDSIND LESEEDKIDF VIDCNLSFQR LIQTASSFVD
TLRSSHKSGL SNKDNIEDVV EDKFVQTADA VEKATLFLRN LMSEIGQGRD MEVHESILNA
ALAITKAVSA LIAAATESQI EIVSRNKGEI SRREFYRKNS RWTEGLISAS KAVAGATNIL
IQTANGILKD ENLHEQLIVA CNEVAASTAQ LVAASRVKAN FVSKTQDNLE SSSRTVNSAC
KSLVSQVQKL IRIDKSTEVG PDLNSLTPYE GKTLEMEQQV EILKLENSLF SARKKLAEIR
KHGYTDDYSG DES
//
