ID   A0A515L917_9SPHN        Unreviewed;       970 AA.
AC   A0A515L917;
DT   16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Insulinase family protein {ECO:0000313|EMBL:QDM40574.1};
GN   ORFNames=C0V74_05610 {ECO:0000313|EMBL:QDM40574.1};
OS   Altererythrobacter sp. TH136.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Altererythrobacter.
OX   NCBI_TaxID=2067415 {ECO:0000313|EMBL:QDM40574.1, ECO:0000313|Proteomes:UP000315722};
RN   [1] {ECO:0000313|EMBL:QDM40574.1, ECO:0000313|Proteomes:UP000315722}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TH136 {ECO:0000313|EMBL:QDM40574.1,
RC   ECO:0000313|Proteomes:UP000315722};
RA   Cai H.;
RT   "Genomes of bacteria within cyanobacterial aggregates.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261}.
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DR   EMBL; CP041409; QDM40574.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A515L917; -.
DR   OrthoDB; 9811314at2; -.
DR   Proteomes; UP000315722; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 2.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000315722};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..970
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5022100293"
FT   DOMAIN          70..189
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          223..397
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          533..656
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          687..866
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   REGION          472..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..506
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   970 AA;  102644 MW;  C25110BE0FD78195 CRC64;
     MHFRFASTSV LALALTACAA APAPQSASSA PVAAAQATAP AAAPLSALVE EVSIPYDSFT
     LANGLTTLVH TDRKTPVVGV TLYYRVGSKN EPRGRTGFAH LFEHLMFGGS ENVESFDVPL
     EAVGSTSTNG STWYDRTNYV ETVPTGALDR ALMMEADRMG HLLGAVTQDK LDKQRSVVKN
     EKRQGDNQPY GLVEYAIGDG LLPVGHPYRH STIGSMADLD AANLTDVRNW FRDHYAPNNV
     VLALAGDIDL ATARAKVEKW FGAIPRGPEV KPVDAPVVGP AAPVRREMTD QVPVTRVTRA
     WTGPGINHAD APALAVGMYI LGGLASSRLD NALVRGDELA VRVSAGNQQQ ELLSFLQADM
     DVKPGTDRAA AEAAFDKVIA DFIARGPTQD EVQRAATKIV SGQIGALEEV GGFGGKGATL
     AEGLLYSNDP ADYKKQLEAI AALTPGQVQD ALQRWLSRPA LTVAVVSGER TEDGATMGGW
     GDEGTVPAPQ PDAKKPVPPI AKSPPIAIPP VEDVGELTFP AIERATLTNG IPVALARRTA
     VPKVMVDLRF NAGYSADGLA RAGTHSLMVS ALDEGTTTRD ATRIAEDQER LGADISTGTS
     LDYDDVFLTA LSANLAPSLE LMADIVRNPA FRADDVARLK NQRAADIAQQ LASPQGLASR
     ALAPLVYGEG HPYGTVGALG TTAVVAKLTP EDLTAEAQAW LRPENARITV VGDVTMAELL
     PQLNQAFGNW SSSEQAPAKK DLPLITPAAE TRLVVIDRPN SPQSVIYAGR LLPVTGATAN
     LESLDLANEV LGSGFLSRLN LLIREEKGWS YGVRTGVTAP EGQRLFTFSA PVQADRTGDS
     VALALDVIGQ FAGGGKGVDA NEFNRVTDGN IRGLPNRFQT NGQVLRALLD LQARGRPDDY
     YTKLPDTYRA IRTNAIDQAA RDYLGAGGLT IVVVGDRDVI DPQLAKLKLP ITYLPADTGA
     PVDTDVSSGE
//