ID A0A517NLR9_9BACT Unreviewed; 365 AA.
AC A0A517NLR9;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 08-NOV-2023, entry version 11.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN Name=dnaA_1 {ECO:0000313|EMBL:QDT08072.1};
GN ORFNames=K239x_00010 {ECO:0000313|EMBL:QDT08072.1};
OS Planctomycetes bacterium K23_9.
OC Bacteria; Planctomycetota.
OX NCBI_TaxID=1930275 {ECO:0000313|EMBL:QDT08072.1, ECO:0000313|Proteomes:UP000319817};
RN [1] {ECO:0000313|EMBL:QDT08072.1, ECO:0000313|Proteomes:UP000319817}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K23_9 {ECO:0000313|EMBL:QDT08072.1,
RC ECO:0000313|Proteomes:UP000319817};
RA Wiegand S., Jogler M., Boedeker C., Pinto D., Vollmers J., Rivas-Marin E.,
RA Kohn T., Peeters S.H., Heuer A., Rast P., Oberbeckmann S., Bunk B.,
RA Jeske O., Meyerdierks A., Storesund J.E., Kallscheuer N., Luecker S.,
RA Lage O.M., Pohl T., Merkel B.J., Hornburger P., Mueller R.-W., Bruemmer F.,
RA Labrenz M., Spormann A.M., Op den Camp H., Overmann J., Amann R.,
RA Jetten M.S.M., Mascher T., Medema M.H., Devos D.P., Kaster A.-K.,
RA Ovreas L., Rohde M., Galperin M.Y., Jogler C.;
RT "Deep-cultivation of Planctomycetes and their phenomic and genomic
RT characterization uncovers novel biology.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|RuleBase:RU004227}.
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DR EMBL; CP036526; QDT08072.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A517NLR9; -.
DR OrthoDB; 9807019at2; -.
DR Proteomes; UP000319817; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000577};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU000577};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000577};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000577};
KW Reference proteome {ECO:0000313|Proteomes:UP000319817}.
FT DOMAIN 58..214
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 273..342
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
SQ SEQUENCE 365 AA; 39836 MW; 916C81CF9F5164EC CRC64;
MIATQPTVTS FPLERPLLRA RWRDATAGNN PALPFFIAGT ENRLITSVCQ SNSGVFDLGN
PVLLIGPTGC GKTSLALHLA AQQAIALGQV QQVGAVKYLP AIDFARGFAE ASAADDMPPF
RAEIDDAPVL VIDDLHLMAD KAPAQEELAA RIEMRTDAQR PTLITCRRLP PEIRSFRPRL
VSRTLHGLTL PIRLPSGEAR RLILRELAMM NDVNLDEALF DALDAGLEDD LSVRALDGAM
KQVSLWCRMN DSAVDLAAIN NAIGATKRSD DVSLGKICRV VARRSGLKTA DLRSSSRKQS
VVRARSLAML IARRQTGNSL DQIGKYFGGR DHSTVLHAIR KSESMLDSDT DLHQTHNDVT
EKLFS
//
