ID   A0A540M6J6_MALBA        Unreviewed;       907 AA.
AC   A0A540M6J6;
DT   16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE            EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN   ORFNames=C1H46_020010 {ECO:0000313|EMBL:TQD94374.1};
OS   Malus baccata (Siberian crab apple) (Pyrus baccata).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=106549 {ECO:0000313|EMBL:TQD94374.1, ECO:0000313|Proteomes:UP000315295};
RN   [1] {ECO:0000313|EMBL:TQD94374.1, ECO:0000313|Proteomes:UP000315295}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Shandingzi {ECO:0000313|Proteomes:UP000315295};
RC   TISSUE=Leaves {ECO:0000313|EMBL:TQD94374.1};
RA   Chen X.;
RT   "Sequencing of a Wild Apple (Malus baccata) Genome Unravels the Differences
RT   Between Cultivated and Wild Apple Species Regarding Disease Resistance and
RT   Cold Tolerance.";
RL   G3 (Bethesda) 9:1785-1793(2019).
CC   -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Acts as an
CC       endogenous post-transcriptional gene silencing (PTGS) suppressor.
CC       {ECO:0000256|PIRNR:PIRNR037239}.
CC   -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC       subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC       ECO:0000256|PIRNR:PIRNR037239}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TQD94374.1}.
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DR   EMBL; VIEB01000345; TQD94374.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A540M6J6; -.
DR   STRING; 106549.A0A540M6J6; -.
DR   Proteomes; UP000315295; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR   CDD; cd18673; PIN_XRN1-2-like; 1.
DR   Gene3D; 1.25.40.1050; -; 1.
DR   Gene3D; 3.40.50.12390; -; 1.
DR   InterPro; IPR027073; 5_3_exoribonuclease.
DR   InterPro; IPR041412; Xrn1_helical.
DR   InterPro; IPR004859; Xrn1_N.
DR   InterPro; IPR017151; Xrn2/3/4.
DR   PANTHER; PTHR12341:SF75; 5'-3' EXORIBONUCLEASE; 1.
DR   PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR   Pfam; PF17846; XRN_M; 1.
DR   Pfam; PF03159; XRN_N; 1.
DR   PIRSF; PIRSF037239; Exonuclease_Xrn2; 3.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW   ECO:0000256|PIRNR:PIRNR037239};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW   Reference proteome {ECO:0000313|Proteomes:UP000315295}.
FT   DOMAIN          24..175
FT                   /note="Xrn1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03159"
FT   DOMAIN          237..683
FT                   /note="Xrn1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17846"
FT   REGION          183..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          818..907
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        830..869
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        880..907
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   907 AA;  103967 MW;  A02FDF6E0CC205E1 CRC64;
     MGVPSFFKWL VNKYPKVVVK AIEDGVAPRA KMNQQRMRRF KSAKDAEFAE VEEEKLRRQF
     ELESKQVLTK QQSEVSDSNI ITPGTEFMHK LSKALRNYIS LRLSNDLGWR DIEIILSDAN
     APGEGEHKIM SFIRSQRNLP SYDPNTRHCL YGLDADLVML ALATHELHFS ILREDVLHNE
     QRHTNCESIR EKGPSSGKSD NKKGSMLKKP YQFLHVWILR EYLELDLKID DPPENFKFDL
     ERIIDDFIFM CFFAGNDFLP HMPTLEIHEG AIDLLMTVYK KELKNLGGYM VDMLRVNDKK
     SGYIKLSRVE KFILLVGSYE DKIFKKRSEL RDRKLRRLCY YNDSLEDEVD TRSIITGSSN
     NQVFLSGEEL EVWSDGTSDI MHSQVVGNTK ELKKKLKDNI RRKSDLFKNG DLGTDKVRFA
     VGGYKERYYK YKFSAEGPED IERKRKEVVK CYTEGLLWVL LYYFSEPPSW TWFYPFHYGP
     FASDLKGLGQ VKAKFHKGFP FKPIDTLMAV LPPRSAHALP KNYQKLMTEE SSGIIDFYPT
     DFEIDMDGKR FTWQGICKLP FIEEERLLSE TKKLDKELVG DERDRNTEKP GQLFVRRTHN
     LVSQIMSLSS KESWSIKIDT SLSFGVGGTI RRLDAAMSEG GDYKLREDHV ACMLYELPNS
     DPHMPRLLDG VKHPSKTITE DDLMETKLWH EYQGSAPTTT TTSSTRLQER YGGFQNNARC
     TSSSTVLIHK FAGSGWGCGR GKEVANPNSG ERFYAPRGIP GERVMSSSSY SAMGSTDHKR
     VSFQGRSVSN DKWRAVGYVS GDRAQGFKDL KISEPSQVWR PKARGQPANA FWPSRNSFGQ
     NTNHSWQSSQ LSHSHGRGRG QQQGGRGQGQ QEYWKRYAPF SANDSSQAGG RSQFVPRSSV
     NQRSAWS
//