ID A0A542SN37_9MICO Unreviewed; 515 AA.
AC A0A542SN37;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=16S rRNA (Cytosine967-C5)-methyltransferase {ECO:0000313|EMBL:TQK75657.1};
GN ORFNames=FB389_0289 {ECO:0000313|EMBL:TQK75657.1};
OS Rarobacter incanus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Rarobacteraceae;
OC Rarobacter.
OX NCBI_TaxID=153494 {ECO:0000313|EMBL:TQK75657.1, ECO:0000313|Proteomes:UP000316181};
RN [1] {ECO:0000313|EMBL:TQK75657.1, ECO:0000313|Proteomes:UP000316181}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10596 {ECO:0000313|EMBL:TQK75657.1,
RC ECO:0000313|Proteomes:UP000316181};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|ARBA:ARBA00007494,
CC ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TQK75657.1}.
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DR EMBL; VFNV01000001; TQK75657.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A542SN37; -.
DR OrthoDB; 9810297at2; -.
DR Proteomes; UP000316181; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.940.10; NusB-like; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR035926; NusB-like_sf.
DR InterPro; IPR006027; NusB_RsmB_TIM44.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF61; NOL1_NOP2_SUN FAMILY PROTEIN _ ANTITERMINATION NUSB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF01029; NusB; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF48013; NusB-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000316181};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 217..514
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 444
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 320..326
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 345
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 373
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 391
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 515 AA; 54594 MW; A59B644A0A235FA2 CRC64;
MNQRSGQGRG GGRDDRPRAR DGRRDSAGHQ RGAARMRGDG RRSAAAPSMR DRSSDEPRAA
AFDVLVDVET NDAYANLVLP ARLARADLGG RDAAFATELA YGTLRMQGHY DAILSECVDR
ALPDIDAPVR VALRLGAHQL LGMRVPAHAA VSQTVGLVRH KIGAGPAQFV NAVLRKVSTK
TADQWQAGIA AQLSDPVELA SFTYSHPAWI VRALKAALVA NGRDPGELEE LLRADNTPAP
VMLVARPGLI DPAELLTHSG GGRVARLSPF AVEAGAVPPR HIAAVKDGRA GVQDEGSQLV
ALALAAAPID GRDKRWLDMC AGPGGKTALL AALAARRGAR VVANEVQPHR AGLVRKNVAA
AAPGSIEAVR TADGRDIGGD EPGSFDRVLV DAPCTGLGAL RRRPEARWRK QPSDLPELSA
LQRELLESAL AAVRPGGIVA YVTCSPHVAE TKLVVDDVIR GRDDIEIVDA ARVLESVVVD
PGDSRVDFGA GPAIQLWPHI HHTDAMHATM LRRLR
//
