ID A0A545UQT0_9HYPO Unreviewed; 404 AA.
AC A0A545UQT0;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 22-FEB-2023, entry version 11.
DE RecName: Full=Prephenate dehydrogenase [NADP(+)] {ECO:0000256|PIRNR:PIRNR036510};
DE Short=PRDH {ECO:0000256|PIRNR:PIRNR036510};
DE EC=1.3.1.13 {ECO:0000256|PIRNR:PIRNR036510};
GN ORFNames=IF1G_09401 {ECO:0000313|EMBL:TQV91816.1};
OS Cordyceps javanica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Cordyceps.
OX NCBI_TaxID=43265 {ECO:0000313|EMBL:TQV91816.1, ECO:0000313|Proteomes:UP000315783};
RN [1] {ECO:0000313|EMBL:TQV91816.1, ECO:0000313|Proteomes:UP000315783}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IJ1G {ECO:0000313|EMBL:TQV91816.1,
RC ECO:0000313|Proteomes:UP000315783};
RX PubMed=31273397;
RA Lin R., Zhang X., Xin B., Zou M., Gao Y., Qin F., Hu Q., Xie B., Cheng X.;
RT "Genome sequence of Isaria javanica and comparative genome analysis
RT insights into family S53 peptidase evolution in fungal entomopathogens.";
RL Appl. Microbiol. Biotechnol. 103:7111-7128(2019).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 +
CC NADPH; Xref=Rhea:RHEA:21640, ChEBI:CHEBI:16526, ChEBI:CHEBI:29934,
CC ChEBI:CHEBI:36242, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.3.1.13;
CC Evidence={ECO:0000256|PIRNR:PIRNR036510};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-
CC hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- SIMILARITY: Belongs to the prephenate/arogenate dehydrogenase family.
CC {ECO:0000256|PIRNR:PIRNR036510}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TQV91816.1}.
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DR EMBL; SPUK01000017; TQV91816.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A545UQT0; -.
DR STRING; 43265.A0A545UQT0; -.
DR UniPathway; UPA00122; UER00962.
DR Proteomes; UP000315783; Unassembled WGS sequence.
DR GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006571; P:tyrosine biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR046825; PDH_C.
DR InterPro; IPR003099; Prephen_DH.
DR InterPro; IPR012385; Prephenate_DH_fun.
DR PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR Pfam; PF20463; PDH_C; 1.
DR PIRSF; PIRSF036510; PDH_fung; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51176; PDH_ADH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036510};
KW NADP {ECO:0000256|PIRNR:PIRNR036510};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR036510};
KW Reference proteome {ECO:0000313|Proteomes:UP000315783};
KW Tyrosine biosynthesis {ECO:0000256|PIRNR:PIRNR036510}.
FT DOMAIN 1..253
FT /note="Prephenate/arogenate dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51176"
SQ SEQUENCE 404 AA; 44738 MW; 49E174AAB54E51B7 CRC64;
MEASQTIPAG MENFVVGLIG MGDMGRMYAE RLSEAGWSVE AAVIDSVIAS YGPSTKMGAI
VGGQTSCKSP EIAAFEKHLP ADVDIVSCHS LHGPGVDPKN QPLVLIQHRA PDASLRRVEA
VLRCLQSKFV HLTALEHDRI TADTQAVTHA AFLSMGKAWH ANRQFPWTMS RYVGGVENVK
VNLMLRIYSQ KWHVYAGLAI LNPEAREQVA QYARSVTDLY KLMLVGDLDG LRRRLYAARD
KVFGTEAWGG NGGDGRPLIE PSVLSSFALG QPSDDDPATR RANNHLSLLA MVDCWAELGI
VPYDHMLCST PLFRLRLGVT EYLFRTPALL DAALVTAVED QTYRSDDLEF TFAARAWAEC
VSLGHFETWR KRFESTQAFF EPRFAEAKVV GDQMMKKVFE SSKP
//
