ID A0A553N6C8_TIGCA Unreviewed; 342 AA.
AC A0A553N6C8;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=pyrroline-5-carboxylate reductase {ECO:0000256|ARBA:ARBA00012855};
DE EC=1.5.1.2 {ECO:0000256|ARBA:ARBA00012855};
GN ORFNames=TCAL_01460 {ECO:0000313|EMBL:TRY60989.1};
OS Tigriopus californicus (Marine copepod).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Hexanauplia; Copepoda; Harpacticoida; Harpacticidae; Tigriopus.
OX NCBI_TaxID=6832 {ECO:0000313|EMBL:TRY60989.1, ECO:0000313|Proteomes:UP000318571};
RN [1] {ECO:0000313|EMBL:TRY60989.1, ECO:0000313|Proteomes:UP000318571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=San Diego {ECO:0000313|EMBL:TRY60989.1,
RC ECO:0000313|Proteomes:UP000318571};
RX PubMed=29988158; DOI=.1038/s41559-018-0588-1;
RA Barreto F.S., Watson E.T., Lima T.G., Willett C.S., Edmands S., Li W.,
RA Burton R.S.;
RT "Genomic signatures of mitonuclear coevolution across populations of
RT Tigriopus californicus.";
RL Nat. Ecol. Evol. 2:1250-1257(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000593};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) +
CC NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000723};
CC -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline
CC from L-glutamate 5-semialdehyde: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005205}.
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000256|ARBA:ARBA00005525}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TRY60989.1}.
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DR EMBL; VCGU01000459; TRY60989.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A553N6C8; -.
DR STRING; 6832.A0A553N6C8; -.
DR EnsemblMetazoa; TCAL_01460-PA_mrna; TRY60989.1; TCAL_01460.
DR OMA; RPYRAMT; -.
DR OrthoDB; 196930at2759; -.
DR UniPathway; UPA00098; UER00361.
DR Proteomes; UP000318571; Chromosome 8.
DR GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 1.10.3730.10; ProC C-terminal domain-like; 1.
DR HAMAP; MF_01925; P5C_reductase; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR029036; P5CR_dimer.
DR InterPro; IPR000304; Pyrroline-COOH_reductase.
DR NCBIfam; TIGR00112; proC; 1.
DR PANTHER; PTHR11645; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR PANTHER; PTHR11645:SF69; PYRROLINE-5-CARBOXYLATE REDUCTASE; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR Pfam; PF14748; P5CR_dimer; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022650};
KW Proline biosynthesis {ECO:0000256|ARBA:ARBA00022650};
KW Reference proteome {ECO:0000313|Proteomes:UP000318571}.
FT DOMAIN 44..122
FT /note="Pyrroline-5-carboxylate reductase catalytic N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF03807"
FT DOMAIN 235..339
FT /note="Pyrroline-5-carboxylate reductase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF14748"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 35958 MW; 549AA694861B5B56 CRC64;
MSLSAPSVTP VPTHPLPMMT TPQNPKMESS MSSSATTVMR LDLKIGFIGG GQMALALAKG
FMASGMVAPS KVLTSAPSDN NLMLWRQLGA NTTHENADVI MGCDVIFLAT KPHIFPAMMA
GLEITGIEED PKSKLQRENG EASNPDNIIS PNTRYITTDS KLFVSVMAGV TIKSLTNALS
NIAFNPRVIR AHPNTPAMVG CGCAVYSLGE GATSDDGDLI RNLFSSVGIC DQVPEYQQDA
FTGMAGSGPA YIYTIIEALS DGGVRMGLPR QMASKFAAQM TMGAAKMALE SGKHTGQLKD
EVTSPAGTTI RGIQVLERAG VRGAVMDAVQ ASAERAVELG KN
//