ID A0A553NP82_TIGCA Unreviewed; 1158 AA.
AC A0A553NP82;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Peptidase M16 N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TCAL_02934 {ECO:0000313|EMBL:TRY67248.1};
OS Tigriopus californicus (Marine copepod).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Hexanauplia; Copepoda; Harpacticoida; Harpacticidae; Tigriopus.
OX NCBI_TaxID=6832 {ECO:0000313|EMBL:TRY67248.1, ECO:0000313|Proteomes:UP000318571};
RN [1] {ECO:0000313|EMBL:TRY67248.1, ECO:0000313|Proteomes:UP000318571}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=San Diego {ECO:0000313|EMBL:TRY67248.1,
RC ECO:0000313|Proteomes:UP000318571};
RX PubMed=29988158; DOI=.1038/s41559-018-0588-1;
RA Barreto F.S., Watson E.T., Lima T.G., Willett C.S., Edmands S., Li W.,
RA Burton R.S.;
RT "Genomic signatures of mitonuclear coevolution across populations of
RT Tigriopus californicus.";
RL Nat. Ecol. Evol. 2:1250-1257(2018).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TRY67248.1}.
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DR EMBL; VCGU01000011; TRY67248.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A553NP82; -.
DR STRING; 6832.A0A553NP82; -.
DR EnsemblMetazoa; TCAL_02934-PA_mrna; TRY67248.1; TCAL_02934.
DR OMA; VGHQWLE; -.
DR OrthoDB; 3042568at2759; -.
DR Proteomes; UP000318571; Chromosome 4.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000318571};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 116..249
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 277..452
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 463..744
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1158 AA; 133769 MW; B3A02F9D605F186B CRC64;
MSSTVMKEER IESCLEKDDP LPDPDPSQSH YPQPQSPVKC CHIRKSLVNS IVSMTTNATC
GKTVHAILDI KMKKKEEELA AVEAAKIMDR KDDIRKQRTD SFKYRYIQLE NGVRLMLVSN
PKATTSAAAL DIKIGSFSDP LHLQGLAHLC EHVLFTGSEG FPNESFSHFL GQRGGSSNAY
TASEHTNFHF DVPSQHFEEA LARFVSFFEC PIFRETSVQS ELDIVQSEHE KNRWNDLWRT
NQVERTTANE NHAFSRFSTG NRKTLTVDEH AHHNLRYELF NFFKTNYSAN LMTVCLVHNR
SLDQMEELAK TNFLRIANRN IPETIWPNRP FKPSQMKTKI YIVPVKDVYH VNLTFPLQDL
HQHYRSSPEG FCAQLIGYKG PNGLFSYLRK IGYAHHLVAG WKNLARGFSF FIITIQMTEI
GERYVDDIVK VVFQYLNLLR AIGPQKWFFD ELQYLSQQQF ESKDLEKVQT YASNVANWLH
IYPPEDCLIA DYVFEDWNRD VIKLVLKHLV PDNVRVTILS KKCRYFTTMV EPHFATEYHV
ERIGEEVLNV WRSCGRNEEH KMPSPNNLID KEMSMVPTDG IRESGLPDLL IYHKRINFLA
WFLPATSSKL AKAFVCVKIS HPDLASVDAT SCALKNLFVA LIRDTLTEYA YQGELAGIFY
SLKPIKTGLE LCVRGYSANQ HIFLKNVLKV LYAYEFEQSR FDQVLEVQMK NMATADGDSL
KAQSKFLLGS ILCPRNYSRK DRLHAYKKSS ISFHHMMDFA HNFRLHNHQE CFFYGNLTTH
QADVLANTIL EARKNFLEQL AQARNVQVES NCLLEEWFVK NPVERVVMLE KALSAKAQSK
VECEHLNGIL EQNVETISCD ASLNQENNFI SPEEPQTMED KGDQSENSNS MDLNQEVRLQ
PTTNQTGYLC LVHNEIQSSS CVLHFLQFRE NTPENHILLE LFLHLVRVRL VSSMKYVVPL
GYVVGCDIRR INNTLGFRII VESQYPLTLV NETIENSLAD LGEYLESIDE ETFHMSREAL
ITTKIESHKR FRDKALNFWK EILDSSYNFQ RLDQELECLR HLDMKSLLQF YRDWIAKTGI
ERRCLILSIG PDPILNCIDG TEAFHLGQEK EKVYESCDTF STPSETQLAS WYQMVFERQD
FEYDPPESST ITCDKAEP
//
