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Database: UniProt
Entry: A0A553NPY7_TIGCA
LinkDB: A0A553NPY7_TIGCA
Original site: A0A553NPY7_TIGCA 
ID   A0A553NPY7_TIGCA        Unreviewed;       232 AA.
AC   A0A553NPY7;
DT   16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Histone H4 {ECO:0000256|ARBA:ARBA00020836, ECO:0000256|RuleBase:RU000528};
GN   ORFNames=TCAL_03755 {ECO:0000313|EMBL:TRY67496.1};
OS   Tigriopus californicus (Marine copepod).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Hexanauplia; Copepoda; Harpacticoida; Harpacticidae; Tigriopus.
OX   NCBI_TaxID=6832 {ECO:0000313|EMBL:TRY67496.1, ECO:0000313|Proteomes:UP000318571};
RN   [1] {ECO:0000313|EMBL:TRY67496.1, ECO:0000313|Proteomes:UP000318571}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=San Diego {ECO:0000313|EMBL:TRY67496.1,
RC   ECO:0000313|Proteomes:UP000318571};
RX   PubMed=29988158; DOI=.1038/s41559-018-0588-1;
RA   Barreto F.S., Watson E.T., Lima T.G., Willett C.S., Edmands S., Li W.,
RA   Burton R.S.;
RT   "Genomic signatures of mitonuclear coevolution across populations of
RT   Tigriopus californicus.";
RL   Nat. Ecol. Evol. 2:1250-1257(2018).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC       {ECO:0000256|ARBA:ARBA00002001, ECO:0000256|RuleBase:RU000528}.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA. {ECO:0000256|ARBA:ARBA00011538, ECO:0000256|RuleBase:RU000528}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the histone H2A family.
CC       {ECO:0000256|ARBA:ARBA00010691}.
CC   -!- SIMILARITY: Belongs to the histone H4 family.
CC       {ECO:0000256|ARBA:ARBA00006564, ECO:0000256|RuleBase:RU000528}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:TRY67496.1}.
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DR   EMBL; VCGU01000011; TRY67496.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A553NPY7; -.
DR   STRING; 6832.A0A553NPY7; -.
DR   EnsemblMetazoa; TCAL_03755-PA_mrna; TRY67496.1; TCAL_03755.
DR   Proteomes; UP000318571; Chromosome 4.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   CDD; cd00074; H2A; 1.
DR   CDD; cd00076; H4; 1.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 2.
DR   InterPro; IPR035425; CENP-T/H4_C.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR002119; Histone_H2A.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR032454; Histone_H2A_C.
DR   InterPro; IPR032458; Histone_H2A_CS.
DR   InterPro; IPR001951; Histone_H4.
DR   InterPro; IPR019809; Histone_H4_CS.
DR   InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR   PANTHER; PTHR23430; HISTONE H2A; 1.
DR   PANTHER; PTHR23430:SF50; HISTONE H2A; 1.
DR   Pfam; PF15511; CENP-T_C; 1.
DR   Pfam; PF00125; Histone; 1.
DR   Pfam; PF16211; Histone_H2A_C; 1.
DR   PRINTS; PR00623; HISTONEH4.
DR   SMART; SM00414; H2A; 1.
DR   SMART; SM00417; H4; 1.
DR   SMART; SM00803; TAF; 1.
DR   SUPFAM; SSF47113; Histone-fold; 2.
DR   PROSITE; PS00046; HISTONE_H2A; 1.
DR   PROSITE; PS00047; HISTONE_H4; 1.
PE   3: Inferred from homology;
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU000528};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000528};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Nucleosome core {ECO:0000256|ARBA:ARBA00023269,
KW   ECO:0000256|RuleBase:RU000528};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000528};
KW   Reference proteome {ECO:0000313|Proteomes:UP000318571}.
FT   DOMAIN          28..93
FT                   /note="TATA box binding protein associated factor (TAF)
FT                   histone-like fold"
FT                   /evidence="ECO:0000259|SMART:SM00803"
SQ   SEQUENCE   232 AA;  25404 MW;  A03577BE3F6E5391 CRC64;
     MTGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK
     VFLENVIRDA VTYTEHAKRK TVTAMDVVYA LKRQGRTLYG FGEYLSEIMS GRGKGGKVKG
     KAKSRSNRAG LQFPVGRIHR LLRKGNYAER VGAGAPVYLA AVMEYLAAEV LELAGNAARD
     NKKTRIIPRH LQLAIRNDEE LNKLLSGVTI AQGGVLPNIQ AVLLPKKTEK KA
//
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