ID A0A553QDB2_9TELE Unreviewed; 706 AA.
AC A0A553QDB2;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
DE Flags: Fragment;
GN ORFNames=DNTS_004174 {ECO:0000313|EMBL:TRY87912.1};
OS Danionella translucida.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danionella.
OX NCBI_TaxID=623744 {ECO:0000313|EMBL:TRY87912.1, ECO:0000313|Proteomes:UP000316079};
RN [1] {ECO:0000313|Proteomes:UP000316079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bolton {ECO:0000313|Proteomes:UP000316079};
RA Kadobianskyi M., Schulze L., Schuelke M., Judkewitz B.;
RT "Hybrid genome assembly and annotation of Danionella translucida.";
RL bioRxiv 0:0-0(2019).
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TRY87912.1}.
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DR EMBL; SRMA01026080; TRY87912.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A553QDB2; -.
DR STRING; 623744.A0A553QDB2; -.
DR Proteomes; UP000316079; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 2.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1.
DR Pfam; PF00801; PKD; 2.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 2.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 2.
DR PROSITE; PS50093; PKD; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000316079};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 631..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..416
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 451..508
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT NON_TER 706
FT /evidence="ECO:0000313|EMBL:TRY87912.1"
SQ SEQUENCE 706 AA; 79373 MW; 16AC8CE9574F2FF9 CRC64;
MKVAGIEGML IANRKVENQV KTYITYNKGR DWRLLQAPTT DLAGNPIHCV LPFCSLHLQL
QMSENPYLSG SISSKSSAPG VIIATGNIGA ELSYNNVAMF LSPDAGNNWR QIFEEEHNVW
FLDKGAALIA VKQPSVPTRI SFDEGRQWTR HSFSAMPLFV DGVLVEAGAQ NQIMTFFGHF
SHRSEWQLIK IDYKSIFTKR CTEGDYQTWH LHNQGEPCIM GQKQIYMKRR PGNYCMVGWE
SSRILSAEPC ICRAHDFECD YGFERRGDGN CLPAFWFNPS KVSQSCSQGQ HFLNSTGYRK
VVANNCTKGV KEIYTARKQQ CPTRPPRGLV LTTRDDKLTA DLNSNVTFLV QLEEGDSMRT
NIQLDFGDGT AVSYSNLSWT LEGIKHVYRS AGIFRVTALA ENSLGFETSS LYLHVTCLVE
HIQLVTPHVA IKKKEVNLTA VVWPSHFRTL TYFWWLGNNT EPIVTLDSSV SHTFSSEGMF
TVTVQVSSGD SVLQDSKSIA VQEFFKSLLL SFSPNLDEAN PDIPEWRQDV ARVIKKAILQ
VADVPEEQLL VAMSPGVPTA AELFLLPPKN RSEGRKQAEE DLEQISEVLV NALNQISVEF
ELKPGSRVIV YITQLTLAPL VDSIPRHSSS AMLMLLSVVF LGLAVFLIYK FKRKIPWINI
YAEVNHEKEQ EMISTVGQNN TTAKITLSEF SSQKELMEKE LEARAK
//
