ID A0A553R9T2_9TELE Unreviewed; 3465 AA.
AC A0A553R9T2;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=TROVE domain-containing protein {ECO:0000259|PROSITE:PS50988};
GN ORFNames=DNTS_016997 {ECO:0000313|EMBL:TRY98944.1};
OS Danionella translucida.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danionella.
OX NCBI_TaxID=623744 {ECO:0000313|EMBL:TRY98944.1, ECO:0000313|Proteomes:UP000316079};
RN [1] {ECO:0000313|Proteomes:UP000316079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bolton {ECO:0000313|Proteomes:UP000316079};
RA Kadobianskyi M., Schulze L., Schuelke M., Judkewitz B.;
RT "Hybrid genome assembly and annotation of Danionella translucida.";
RL bioRxiv 0:0-0(2019).
CC -!- SIMILARITY: Belongs to the apolipoprotein L family.
CC {ECO:0000256|ARBA:ARBA00010090}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TRY98944.1}.
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DR EMBL; SRMA01025124; TRY98944.1; -; Genomic_DNA.
DR Proteomes; UP000316079; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006869; P:lipid transport; IEA:InterPro.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 5.
DR InterPro; IPR008405; ApoL.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR045804; DUF5920.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008858; TROVE_dom.
DR InterPro; IPR037214; TROVE_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44791:SF1; TELOMERASE PROTEIN COMPONENT 1; 1.
DR PANTHER; PTHR44791; TELOMERASE PROTEIN COMPONENT 1 TEP1; 1.
DR Pfam; PF05461; ApoL; 2.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF19334; DUF5920; 1.
DR Pfam; PF05731; TROVE; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 15.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF140864; TROVE domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50988; TROVE; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000316079};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 214..660
FT /note="TROVE"
FT /evidence="ECO:0000259|PROSITE:PS50988"
FT REPEAT 1722..1763
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1763..1795
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1805..1846
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1952..1993
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1997..2036
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2412..2442
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 2285..2352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2517..2583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2966..2993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3251..3278
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3400..3459
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2538..2554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2556..2576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2977..2992
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3465 AA; 389465 MW; 0E89F05A029C011B CRC64;
MKAPLVLHSD QKANIDKRLR QTCTTPGLEN RILVEAASAL TQHQVQYTAP SWTCTECAAL
QPTTLSSTKS SYSLSSSTTL SSIPTTSSLL STKNTLLKEP QLHLPVLSSL TSISVQNPVL
PSSKMSSASA IPPVCSYPSA SVKNPERSDD KKYVVDRDSS EEALIENREE FKQVSTQESL
EEDDEMSSEV PVLDMDLDGE SEQLVAPREE FGAVERSMNE QLLELKEQKN NLLSVVCCSL
VHKNCTPGQK EWDTKKSVWS IIRNLASEIT TEDPEFVLKV AVYTRQELNI RITANFLLAL
AANLPASKPH LRRYFRAAVQ LPSDWLEVAR FYSMCFSKSL PACLKKALVD KFKDFTEYQL
AKYNTRKHRC KHSKKKNKIE NISPEDWKKW GELVKVDDLV LKKYLTSQNR AKMDKKQSQF
SLKKMIKRLH IKESAEMVMA ILGKKYPNDV KAFSRSGLTG VWDRERAGKQ MKLKQPDTWE
RKLSQEGNKA ATWEKLIDEK SLPFMAMLRN LRNLITVGIS QRHHAKILNR LTSKNAVIKS
RQFPFRFLSA YKAVLELYKF ASGPSVKPQS SSEILRDILK KLPRTRRYRQ NKVDWEQAER
KKLRITMRVP FVYRLFNVKR KLLRQANRRL YTQDLLKKYC CALEKAIQIS CKFNIPPLPG
CSIFICNITY VLVDMDWKNE DVCLPPKITD ELGENEQKLE PMDLAMLLCM MMKYCSEDSQ
IILQRDEKFH KLKLKADDDD LLENVRQAME LVKVDRIVVF ERYYDVDSLM MEINNYRLET
NQETIVMDVQ VGRPSAEEVS YMQCSNTMQV WGFSEQILKF VSERGSLRML QHVENIDKVY
NIPPPQEGKS EPERSADIVP LPATPKFRWK GVRVFISSTF RDMHAERDVL VRSVFPELRR
RAATHYLYLQ EVELRWGVTE EESNRAVELC LSEVCRSQLL IGILGQRYGL VPVRPSLPEL
PQYSWLNSTS DGLSITEMEI RQFQALYPDS AQSRMFFYFR SSDLTSSVPV AWRADFVAES
KEAEAKMNSL KSWIRNSEFK VTENYPCEWG GVTDGKPYVK RLEEFGRATL EDIWEAVQQL
FVQENDEEST SEITEQEVHQ GAQHRQFHGR AKLVSMATEK IQEAQLKGGI LMVEGKPGEG
KTVFMSLKST DNYKKAPLCD VIIYSTDASQ SACSVDQLLR CLIQWLRNMK DDVELPPKSP
ASYKDLLSDF LMKLKDHPKE KPLVLFVDGA DRIHDDRGQK VSEWIPQHIP KSVCLVLSVT
SDSHLQNTLS KKKGTISFPL GQLSLPDKKE IVQKKLVGFG KKLSDAAFNN QLQTLLMKKG
SVSPLYLHMA CEELRSYASF EKMKEILQSF PQSLGELVQH SLLRLESEYC SAGIGWTLAT
LAISSNGLRE SNLYTMLNMC NDLILRGGQV TWQETLHIAR HPESRVPMAV FSQLARTLHS
LIGASHSQGA DDLLTLTHPE VKSAFEHLYL SSEESRRRSH LIMAAHIWMQ SNPQGKDMFL
QSDAESLSHL PGHLMSCNQW EPLCFLLSNY YFVYANVRHG LLHQLMETYI LFSQKYNTLE
LKSSKSTANM REFEDCLGFL KRHSHLFSQW PALFVQTALN EPGDSSAHLW AASMSRNARV
QAVKWMNYTD AVQTEVSELV SIFQSEPSCV VLSPDGQHAA IGTGEGTIHL LDSKTGQEVK
SFTSNTDGIS GCIFLEEVLV ATSFDGQLEV WDVASGCRIA LITAHSNKIT GCDASPDRKL
FATVSLDLSL KVWSAKKNSE VACLGNPTPL NCVKFDPEGQ LLAVGCWDGT VSLWNWLEQK
NVAILLGHQS SVRSLSFSPS SSILCSGCIS GEVRLWSVAA AACVGSFHAH CGSTQSLSFL
QGGNVLLSAG QDREKVWASD NLQVSMLCLM WMEGEGGDIL LSGGMDHHIR VWERQGETLA
PVGSFDNFTI ALWLKSELTF KSLTDPTPVS ILRGHNGGVT CLAFSPNGKE LLSGGKDQAL
MIWNLNLSHP ALSQSIPHCH GDWITGCAWT SSAVLSCSSD CKLRVWDVQT GNMLREILST
SSLTSMCLRE EHVLAGSTDG LLMVWKWESG VEVTRMQAHK SRLNHCSVVT QPETPQTKKG
GIRSLCFLET DDLLVCGYDT GRLEIWHQKS MVYWKKVSEG SLCSLAEMPN DELAVGCIDC
SVCVWRLKRG VKNCIVGLSK VSSYKLESAA AYLVYCCTLF GACMDGRILD VISTASETKE
DTCWSNKVHP IGMMKNDNKS FWMLGKKRNA VGKKLEDLEY DIKCREDTDE EQRHGQLEAQ
QLEEKQLEDQ ENQEKQLEDQ EDQEKQLKDQ ENQENKLGDQ EDQEKQLENH EAEEQQQEGD
KEEEQLEKPV KKLSEEEIKQ RRLQEIEIQK VTQISSWITA AAVHNDLFVC GDLKGNIWFN
KPPDLSSWTE RKPAHTDKVK VLRLTESLVI SGSSDRTIKL WDRCTKKQVG MFVCGAPVRA
IEVNPRDSRE FVCGDSQGQL YFLSWKVSIT DSSNVKMDHE EMKTDDNDIK ASANKEMVPE
TSVNHPADVQ SHSNHELSDG NEVLEKKDDL VTSGDNPKNK VIQKKSETQN GGSGSDLGEP
EGTKKSLIEW LEEFRSSESQ REEEDLDGLM DWWNNVEQWE DMPKNDNLTE KEEAKAFAGT
AEKVQKGIRL FNKLFSERAE ALWQHVIDLY AIADGLDRFN KKTKIAQITG GSTSAVGGVA
TITGLILAPF TMGTSLIVTA VGLGVAMAGG LTSASAGISS TVNNSLDRKK VERIVEDYQA
KMGDLNKCMK FIKQGLTNLR KFNLNKMKKH AYNRDFPCLD NIYEDGAMAS KAILSNANEI
MRVMQLANAA GTTAARAVQI ASISSGVLTG LFVGMDIYFV AKDSHELKNG AKSEFAAKIR
EVAEQLQEGL MELNIIREEM RMTATSHEKP LDFLSLNKTQ RDSMSRLSDG AGRSAEKRED
KFKNVGAANI HTEELNIVLN GSYRPDGSLL ENSNSKRRNS QFKEDTSDED SPPLHIKLLA
VNDHLLQPSY NNIKVSSRKP NGTLARSPKP ALRFAAQTQI NDVDKSASDE EKALNCSMKS
EEKFINNIHI FNQHKDQEHI LQPMEIEQPA DSTFEILPVE IAPYPTNLDS LETDEDGDLM
DWWKTVEGWS EWNETTHLQE DDEKLAVEAA ADRVFMAARL FVSLFNQRGV SLQCRIVELL
ALADAADNFH KKTVGAAVGG GVASVAGGIA TITGLILAPF TFGTSTIVTA VGISVATAGT
ITSATANITD AVQSKTDRKK VEKMIQDYQN EINDIRDCLE FMQEGMNTLQ EWEFKQYSES
VVNASLNRNI KHVMKEGGRA GRALMVNTDR LISTVKVLGV AGGAAKAAKA ISITTGVMST
LFLALDVFFL AKDSNELRKG AKTKFASKIR EVCKELQHGL LELNKVKAQL QKTMDGIEVE
EYEQEMEEED QSESDPVKLA LLEQELDQLE EKLDKKVVGE LINHS
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