ID A0A565CI91_9BRAS Unreviewed; 145 AA.
AC A0A565CI91;
DT 16-OCT-2019, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=PHD finger protein ALFIN-LIKE {ECO:0000256|RuleBase:RU369089};
GN ORFNames=ANE_LOCUS23799 {ECO:0000313|EMBL:VVB13355.1};
OS Arabis nemorensis.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis.
OX NCBI_TaxID=586526 {ECO:0000313|EMBL:VVB13355.1, ECO:0000313|Proteomes:UP000489600};
RN [1] {ECO:0000313|EMBL:VVB13355.1, ECO:0000313|Proteomes:UP000489600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dittberner H.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Histone-binding component that specifically recognizes H3
CC tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription
CC start sites of virtually all active genes.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369089}.
CC -!- DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SIMILARITY: Belongs to the Alfin family.
CC {ECO:0000256|RuleBase:RU369089}.
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DR EMBL; CABITT030000008; VVB13355.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A565CI91; -.
DR Proteomes; UP000489600; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR InterPro; IPR045104; Alfin.
DR InterPro; IPR021998; Alfin_N.
DR PANTHER; PTHR12321; CPG BINDING PROTEIN; 1.
DR PANTHER; PTHR12321:SF39; PHD FINGER PROTEIN ALFIN-LIKE 3; 1.
DR Pfam; PF12165; Alfin; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|RuleBase:RU369089};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU369089};
KW Nucleus {ECO:0000256|RuleBase:RU369089};
KW Reference proteome {ECO:0000313|Proteomes:UP000489600};
KW Transcription {ECO:0000256|RuleBase:RU369089};
KW Transcription regulation {ECO:0000256|RuleBase:RU369089};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU369089};
KW Zinc-finger {ECO:0000256|RuleBase:RU369089}.
FT TRANSMEM 93..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..140
FT /note="Alfin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12165"
SQ SEQUENCE 145 AA; 16829 MW; 2995972E89443B26 CRC64;
MYRTTHPPPN TNPSTVEEIF ADINGRRSGF LQAFFVDVDS VFALCNPEEE ELCLYAYPNE
RWNVSPPHLQ VPPDIPEPVL GINFVRDGMP RKAWLQFVAG HCDSWLLYLA FFFGCRLNRH
ERTRLFDLID AQPTLYEQVT NRPSE
//
