ID A0A5A7SQD5_CUCME Unreviewed; 1034 AA.
AC A0A5A7SQD5;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=E6C27_scaffold111G00560 {ECO:0000313|EMBL:KAA0033404.1};
OS Cucumis melo var. makuwa.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=1194695 {ECO:0000313|EMBL:KAA0033404.1, ECO:0000313|Proteomes:UP000321393};
RN [1] {ECO:0000313|EMBL:KAA0033404.1, ECO:0000313|Proteomes:UP000321393}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. SW 3 {ECO:0000313|Proteomes:UP000321393};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAA0033404.1};
RA Kwon S.-Y.;
RT "Draft genome sequences of two oriental melons (Cucumis melo L. var
RT makuwa).";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0033404.1}.
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DR EMBL; SSTE01020868; KAA0033404.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5A7SQD5; -.
DR STRING; 1194695.A0A5A7SQD5; -.
DR Proteomes; UP000321393; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000321393};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..44
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 62..92
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 121..162
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 163..204
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 691..891
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 418..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 113583 MW; E7DC46F89353BA41 CRC64;
MIAEKPSWVR HEGMQIFSID VQPGGLRFAT GGGDHKVRIW NVKSVGRSLE DDDSNQRLLA
TLRDHFGSVN CVRWAKHGRY VASGSDDQTI LVHEKKPGSG TTEFGSGEPP DVENWKVAMT
LRGHTADVVD LNWSPDDSTL ASGSLDNTVH IWNMSNGICT AVLRGHSSLV KGVAWDPIGS
FIASQSDDKT VIIWRTSDWS LAHRTDGHWT KSLGSTFFRR LGWSPCGHFI TTTHGFQKPR
HSAPVLERGE WSATFDFLGH NAPVIVVKFN HSMFRRNLTN ANEMKAVPVG WTNGGSKIGG
KESPSYNVIA IGSQDRTITV WTTASPRPLF VAKHFFTQSV VDLSWSPDGY SLFACSLDGS
VATFHFEVKE IGQRLPDAEL DEIKRSRYGD VRGRQVNLAE TPAQLMLEAA SLRQVSSKKV
VPETQQNQTP AKPSIDARDG TKILEPQVDD SKKTGGASGD SLNKVSSAPP KISSPVKQRE
YRRPDGRKRI IPEAVGVPVQ QENKSGGIQS SNAVDFPSLS SDQKKDNNGV AAPECVRENF
VRGAPSKHTD SKERTGVTAR TTITDSLVIE KVPLSEGKDE NIIMDHPGNL KTSSSLATCS
SVLSIRVFDK KEGEYNEPIC LEARPKEHAA NDIIGAGNTS MLKETVISCT KGSRILWSDR
VSGKVTVLAG NANFWAVGCE DGYLQVYTKC GRRSMPTMMM GSAATFIDCD DCWKLLLVTR
KGSLYVWDLF NRSCLLHDSL ASLIPLNPNS STKDSGTIKV ISAKLSKSGS PLVVLATRHA
FLFDMSLMCW LRVADDCFPA SNFSSSWNLG SIQSGELAAL QVDIRKYLAR KPGWSRVTDD
GMQTRAHLET QMASALALKS PNEYRQWLLS YIRFLAREAD ESRLREVCES LLGPPTGMAG
DALADTKNQA WDPCVLGMRK HKLLREDILP AMASNRKVQR LLNEFMDLLS EYENNENNID
PKASLPAASS LQEPDHEHSA PQQADKMETD ATLPQLKDSS ELEIDQTSFA PPVAPVDLGQ
PVKNLINLAS EAKN
//
