ID A0A5A9PDI8_9TELE Unreviewed; 1789 AA.
AC A0A5A9PDI8;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=5'-3' exoribonuclease 1 {ECO:0000313|EMBL:KAA0719059.1};
GN ORFNames=E1301_Tti007623 {ECO:0000313|EMBL:KAA0719059.1};
OS Triplophysa tibetana.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Nemacheilidae; Triplophysa.
OX NCBI_TaxID=1572043 {ECO:0000313|EMBL:KAA0719059.1, ECO:0000313|Proteomes:UP000324632};
RN [1] {ECO:0000313|EMBL:KAA0719059.1, ECO:0000313|Proteomes:UP000324632}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TTIB1903HZAU {ECO:0000313|EMBL:KAA0719059.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:KAA0719059.1};
RX PubMed=30977968;
RA Yang X., Liu H., Ma Z., Zou Y., Zou M., Mao Y., Li X., Wang H., Chen T.,
RA Wang W., Yang R.;
RT "Chromosome-level genome assembly of Triplophysa tibetana, a fish adapted
RT to the harsh high-altitude environment of the Tibetan Plateau.";
RL Mol. Ecol. Resour. 19:1027-1036(2019).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA0719059.1}.
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DR EMBL; SOYY01000007; KAA0719059.1; -; Genomic_DNA.
DR Proteomes; UP000324632; Chromosome 7.
DR GO; GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR016494; 5_3_exoribonuclease_1.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF006743; Exonuclease_Xnr1; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000324632};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1789
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5022694130"
FT DOMAIN 170..396
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 443..773
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT DOMAIN 821..1006
FT /note="5'-3' exoribonuclease 1 D1"
FT /evidence="ECO:0000259|Pfam:PF18332"
FT DOMAIN 1014..1239
FT /note="Exoribonuclease Xrn1 D2/D3"
FT /evidence="ECO:0000259|Pfam:PF18334"
FT DOMAIN 1267..1336
FT /note="5'-3' exoribonuclease 1 SH3-like"
FT /evidence="ECO:0000259|Pfam:PF18129"
FT REGION 1350..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1491..1513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1707..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1351..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1709..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1732..1746
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1753..1768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1789 AA; 202242 MW; DF86544FA394343A CRC64;
MIFVLTLAFL VALSWGLPKD IVIQFERSVS INGTIVERIS INGPSDSYLK GNSAKHPVVR
SIQDDALMII MRHATTNNGT YIRLRECTLR GYQVCGLSDR VQLNGKDYLT LDPDAVSWTV
LMPEASDIKK IWALEIELAG HEKSHLKQDC EEFFKQMNEN GNQEELSEKM GVPKFYRWIS
ERYPCLSEVV KEHQIPEFDN LYLDMNGIIH QCSHPNDEDV HFRISEEKIF ADIFHYLEVL
FRIIKPRKVF FMAVDGVAPR AKMNQQRGRR FRSAKEAEEK IKKALEKGEV LPTEARFDSN
CITPGTDFMA RLQEQLKYFV HNKLSTDKTW QGVNVYLSGH ETPGEGEHKI MEFIRSESAK
PSHNPNTRHC LYGLDADLIM LGLTSHEPNF SLLREEVRFG GKKSQKRITA PEETTFHLLH
LSLMREYIDY EFSELRKKIT FEYDLERIID DWVLMGFLVG NDFIPHLPHL HINHDALPLL
YRTYINVLPS LGGYLNENGH LNLGRFEKYM EKLSDFDREH FSEVFVDLKW FESKVGNKYL
NEAAGLAAEE ADAKVLKSKS SDDSLCLAAL DGVKGTHTSG KEGTEEDGED DDMFETEFRQ
YKRTYYMTKI GVEVVSDEFL ANQAKCYVEG IQWILHYYYH GVQSWSWYYP YHYAPFLSDV
RNISTLKLTF DLAKPFMPFE QLLGVLPAAS KDLLPQCYQH LMTSLTSTII EYYPQDFKTD
LNGKQQEWEA VVLIPFIDEK CLLAAMEPCM LKLTPSEKAR NRHTECAVYC FDKELDYTYD
SPLPQMLPNI LHCRVRQTPI PMDAWHVSVE HVGCRIDRGA LYFCGFPTLQ HIRHKFYKKK
SGVVVFQQSS RGENTILEIL PGQEVEQVEV VATVVLGKSL FVNWPHLMEA RVVAVSDGET
KFALEEQSGS QLLYMEDIPP PTKVNHLTDK EQKDWIKEVQ GLSEYFSKRK GIVIGDTDVV
MYAQLLIGRK YVIGQNGKVH LEKQFAKQIL PFPHQTIVKD IKAFDSSLAR FKTLEELFPP
GTSVFMVGNP YYGAMGDVQD SSDVINEGRV RVVFSVPCEP QLDALIQNQH KYSVKYSPGY
VLASRLGITS YLVSRFSGSI FIGRGSKKNP HGEQKVNAGL NLKFNKKNEE VPGYTKRTEK
EWLYSSAVEE LIAEYLERFS EVFDLVARNS HDDVFYEDDI WPGEDENGSE KIQEIQAWLK
AHPVSSSSRA SCDLHILDAG IVEKIEEEVE KTKVKKMNKK VRVTVKPHLL FRPLEQQHGV
VPDPDAEYHL FDRVVNVRES FSVPLGLRGT ITGIKGAERE TEVLYEVLFD EDFAGGLTIR
CSTGRGYRLP PSALINLSHG SRKEHKLTAI VKPQPSSSHP THKSHLGGLN HSPRSPFIPT
QQQNGRQGLN LRADTQGNRS SPHKALNQKN QHKGSGNEKE FSNVWQSLQG TGMPQNPPAH
WQNNAEKSSG LLSQQRQPEG QKPNQYIDPF NKPVSSEFEE LIANLKISKD PEPAQHYPHQ
EPKSQSGEPL SPQSFAMKGT LMLKEMLKID SSGTSSSAPE STLLSEGQNS SNPNVQQLNK
RRSSKKLAAC INTPQTETPP PPPLAGQPPI MPSMAAELGR ICMGLGMGPP EFAILRNRQN
LMVCQVNLSN GLLVHGPQCQ SETEAKEKAA LFALQRLNSL GSFPVPPPIF PGVQQMRPLA
PHPSIFGQPP GKCFLYQVTK KRVSGRTKYQ DAKQFSSFQA QSSGPSQPAS SPPSASKTPP
PGTDKPTEKP MATTPKTPRQ SANPHTPGSA SKRKHRKLAV NFEAAKVTD
//
