ID A0A5B1QIP4_9AGAM Unreviewed; 1128 AA.
AC A0A5B1QIP4;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Insulin-degrading enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=DENSPDRAFT_835009 {ECO:0000313|EMBL:KAA1469392.1};
OS Dentipellis sp. KUC8613.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Russulales; Hericiaceae; Dentipellis.
OX NCBI_TaxID=1883078 {ECO:0000313|EMBL:KAA1469392.1, ECO:0000313|Proteomes:UP000322482};
RN [1] {ECO:0000313|EMBL:KAA1469392.1, ECO:0000313|Proteomes:UP000322482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KUC8613 {ECO:0000313|EMBL:KAA1469392.1,
RC ECO:0000313|Proteomes:UP000322482};
RX PubMed=31482283; DOI=.1007/s00253-019-10089-6;
RA Park H., Min B., Jang Y., Kim J., Lipzen A., Sharma A., Andreopoulos B.,
RA Johnson J., Riley R., Spatafora J.W., Henrissat B., Kim K.H.,
RA Grigoriev I.V., Kim J.J., Choi I.G.;
RT "Comprehensive genomic and transcriptomic analysis of polycyclic aromatic
RT hydrocarbon degradation by a mycoremediation fungus, Dentipellis sp.
RT KUC8613.";
RL Appl. Microbiol. Biotechnol. 103:8145-8155(2019).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA1469392.1}.
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DR EMBL; NSJX01000006; KAA1469392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B1QIP4; -.
DR InParanoid; A0A5B1QIP4; -.
DR Proteomes; UP000322482; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000322482};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 53..187
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 269..442
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 455..749
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 753..935
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1128 AA; 127681 MW; BC6AC582011BED6B CRC64;
MTAGIPEDEA NWRPAKSLKG TNYFIFDKSI EKSQQDDREY RLIRLENGLQ AMIVHDATAD
KAAASLDVAV GHLNDPDDMP GLAHFCEHLL FMGTEQFPKE NEYNEYLSKN NGSSNAYTAA
SNTNYYFTVA TPALTGALAR FSGFFHSPLF APSCTNRELN AVDSENKKNL QSDVWRIFQL
NKHLTKPGHP WSKFGTGNKE SLTKVGRDLK ARQTAANGVD KKARLSAATS IDNSLAPSPL
SSRAVSPAPS VNSAVSEIEA DGGTVGRETR RRLIEWWTEN YCASRMRLCV IGKESLDDLS
ETVIEFFSPV LNRGKDPLPM ITDHPFGPAE KGKLISVQTI MAFHAIEISF PLADQVPLYR
YKPANLLSEF IGHEGPGSVH SYLKEKGWIT SLNAGPQSLG RGFAMFKVTI HLTKEGFRHY
REAALAVFNY LSLLRSTEVP AWYSQEFSKI METRFRFTEK GRPEDYAVWV SEHMGRPVPR
ELVLKASQVM SEWDPEGVAE KEMRRALEGL RIFEGRAVLM ARKDDHEEVA GRKEWDTEPW
YQTAYRVEKF DDDFVQKAEG PNVIPQLHLP NPNNFVPQNL DVDKREVEKV EKRPHLIRQT
PSSTLWHKKD DRFWIPRAHA LLDIRTPYAS STPEAAVLTR LFVNLVNDAL NEYAYAADLA
GLNYNLTSFR LGIYVGVGGY NDKLHVLLKT VLERIKSLQV RSDRLEVSRE QMKRDWENFL
LGQSYTISDY YSRYLMTDSQ WTIPELLDAL AVVTVQQVQD HATKLLSKIH TLMLVQGNLY
KDEAVNIAKM SEEILGGAPM GPYDCTESAC FPKESTNLVW STPVPNPNEP NSALTYYLHL
GSYNERPLRV ASSLLSQIIS EPAFNILRTK EQLGYIVGAS LWQSNGSHEI GLRIVVQSER
GPVYLEERVE AFLNHMKGVL EAMSDAEFQE QKDGLEKKRR EEPKNLSEEV QRFWSQIDSG
YLDFYRRSED ADYLKTVTKT DVIALFSKYL LPSSTERKKL SVHVKSQMPR TKHVSSAAMD
AFAQHLKDAN VALEDVNWRE ELEGEPTVAD FKKYWTGVFT ERSIKDTDSL LSVVSGLVEK
YPATKDAEGA LRSDVKQIED IKAFKASLRI TDPPKPLVEW NDLPVPKF
//