ID A0A5B6WDB1_9ROSI Unreviewed; 253 AA.
AC A0A5B6WDB1;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=PHD finger protein ALFIN-LIKE {ECO:0000256|RuleBase:RU369089};
GN ORFNames=EPI10_019722 {ECO:0000313|EMBL:KAA3479187.1};
OS Gossypium australe.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=47621 {ECO:0000313|EMBL:KAA3479187.1, ECO:0000313|Proteomes:UP000325315};
RN [1] {ECO:0000313|Proteomes:UP000325315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. PA1801 {ECO:0000313|Proteomes:UP000325315};
RX PubMed=31479566; DOI=10.1111/pbi.13249;
RA Cai Y., Cai X., Wang Q., Wang P., Zhang Y., Cai C., Xu Y., Wang K.,
RA Zhou Z., Wang C., Geng S., Li B., Dong Q., Hou Y., Wang H., Ai P., Liu Z.,
RA Yi F., Sun M., An G., Cheng J., Zhang Y., Shi Q., Xie Y., Shi X., Chang Y.,
RA Huang F., Chen Y., Hong S., Mi L., Sun Q., Zhang L., Zhou B., Peng R.,
RA Zhang X., Liu F.;
RT "Genome sequencing of the Australian wild diploid species Gossypium
RT australe highlights disease resistance and delayed gland morphogenesis.";
RL Plant Biotechnol. J. 0:0-0(2019).
CC -!- FUNCTION: Histone-binding component that specifically recognizes H3
CC tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription
CC start sites of virtually all active genes.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBUNIT: Interacts with H3K4me3 and to a lesser extent with H3K4me2.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU369089}.
CC -!- DOMAIN: The PHD-type zinc finger mediates the binding to H3K4me3.
CC {ECO:0000256|RuleBase:RU369089}.
CC -!- SIMILARITY: Belongs to the Alfin family.
CC {ECO:0000256|ARBA:ARBA00010445, ECO:0000256|RuleBase:RU369089}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAA3479187.1}.
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DR EMBL; SMMG02000003; KAA3479187.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B6WDB1; -.
DR Proteomes; UP000325315; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR CDD; cd15613; PHD_AL_plant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045104; Alfin.
DR InterPro; IPR021998; Alfin_N.
DR InterPro; IPR044104; PHD_AL_plant.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12321; CPG BINDING PROTEIN; 1.
DR PANTHER; PTHR12321:SF183; PHD FINGER PROTEIN ALFIN-LIKE; 1.
DR Pfam; PF12165; Alfin; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|RuleBase:RU369089};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU369089}; Nucleus {ECO:0000256|RuleBase:RU369089};
KW Reference proteome {ECO:0000313|Proteomes:UP000325315};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU369089};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU369089};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU369089};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 197..249
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 147..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 253 AA; 28585 MW; 1815A7525B963D74 CRC64;
MEGGGAQYNP RTVEEVFRDF KGRRAGMIKA LTTDVEEFYQ QCDPEKENLC LYGFPSEQWE
VNLPAEEVPP ELPEPALGIN FARDGMQEKD WLSLVAVHSD AWLLSVAFYF GARFGFDKAD
RKRLFNMIND LPTIFEVVTG GVAKKQTKEK SLVSNHSSNK SKSNSKARES QAKHSKASQP
KDEEQGLDEE DEDEHGETLC GACGENYASD EFWICCDACE KWFHGKCVKI TPARAEHIKQ
YKCPSCSNKR ARP
//
