ID A0A5B7E7D2_PORTR Unreviewed; 331 AA.
AC A0A5B7E7D2;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 9.
DE SubName: Full=Digestive cysteine proteinase 3 {ECO:0000313|EMBL:MPC28644.1};
GN Name=LCP3 {ECO:0000313|EMBL:MPC28644.1};
GN ORFNames=E2C01_021855 {ECO:0000313|EMBL:MPC28644.1};
OS Portunus trituberculatus (Swimming crab) (Neptunus trituberculatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Portunoidea; Portunidae; Portuninae; Portunus.
OX NCBI_TaxID=210409 {ECO:0000313|EMBL:MPC28644.1, ECO:0000313|Proteomes:UP000324222};
RN [1] {ECO:0000313|EMBL:MPC28644.1, ECO:0000313|Proteomes:UP000324222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Muscle {ECO:0000313|EMBL:MPC28644.1};
RA Jeong J.-H., Song I., Kim S., Choi T., Kim D., Ryu S., Kim W.;
RT "Another draft genome of Portunus trituberculatus and its Hox gene families
RT provides insights of decapod evolution.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MPC28644.1}.
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DR EMBL; VSRR010001945; MPC28644.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B7E7D2; -.
DR Proteomes; UP000324222; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF1020; INHIBITOR_I29 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000324222};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..331
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023072646"
FT DOMAIN 30..90
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 116..330
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 331 AA; 37460 MW; A8815CD87F05BED9 CRC64;
MQRPMNKMKA FVLLACTVVL AAATPSYNEW QRFKIQFGKQ YRSSQEEEYR KSVFEQNQEF
IDNHNKKFED GLVTFTLKMN QFGDLTTDEI NHMMNGYRGS QRRHTMILHQ SKEEELPKTV
DWRKEGAVTP VKDQKACGSC WAFSTTGSLE GQHFLASKKL VSLSEQNLVD CSDKYGNFGC
GGGLMDNAFR YIKNNNGIDT EQSYPYEAKN GPCRFKAGDV GATLTGYVDI QKDSEKDLQH
AVAKKGPISV AIDASRPTFH FYSSGIYYDE HCSSTFLDHG VLAVGYGTDS SEYWLVKNSW
NESWGDKGYI KMSRNRNNNC GIATQASYPL V
//
