ID A0A5B9DDQ3_9ARCH Unreviewed; 860 AA.
AC A0A5B9DDQ3;
DT 13-NOV-2019, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Protein disaggregation chaperone {ECO:0000313|EMBL:QEE17449.1};
GN ORFNames=DSAG12_03286 {ECO:0000313|EMBL:QEE17449.1};
OS Candidatus Prometheoarchaeum syntrophicum.
OC Archaea; Asgard group; Candidatus Lokiarchaeota; Candidatus Lokiarchaeia;
OC Candidatus Prometheoarchaeales; Candidatus Prometheoarchaeaceae;
OC Candidatus Prometheoarchaeum.
OX NCBI_TaxID=2594042 {ECO:0000313|EMBL:QEE17449.1, ECO:0000313|Proteomes:UP000321408};
RN [1] {ECO:0000313|EMBL:QEE17449.1, ECO:0000313|Proteomes:UP000321408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MK-D1 {ECO:0000313|EMBL:QEE17449.1,
RC ECO:0000313|Proteomes:UP000321408};
RX PubMed=31942073;
RA Imachi H., Nobu M.K., Nakahara N., Morono Y., Ogawara M., Takaki Y.,
RA Takano Y., Uematsu K., Ikuta T., Ito M., Matsui Y., Miyazaki M., Murata K.,
RA Saito Y., Sakai S., Song C., Tasumi E., Yamanaka Y., Yamaguchi T.,
RA Kamagata Y., Tamaki H., Takai K.;
RT "Isolation of an archaeon at the prokaryote-eukaryote interface.";
RL Nature 577:519-525(2020).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675}.
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DR EMBL; CP042905; QEE17449.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5B9DDQ3; -.
DR KEGG; psyt:DSAG12_03286; -.
DR OrthoDB; 9837at2157; -.
DR Proteomes; UP000321408; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042026; P:protein refolding; IEA:InterPro.
DR GO; GO:0009408; P:response to heat; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR017730; Chaperonin_ClpB.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03346; chaperone_ClpB; 1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000321408};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 3..147
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT COILED 413..541
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 860 AA; 98070 MW; 9EFE697C7581D9E7 CRC64;
MELNRFTIKL QEAMLKAKNK AQKQKNQQIE IEHLIFAFLS DPENIANLIF QKTGANSNQI
QNEIENEIKR YPQVTGNTSE VYLSKSLNNT INEAMSVMED MKDQYLSAEH VILTISKDNS
TNVSGIFLKH GLTYERILQA ISEFRGNISI DNPNPETQYQ PLEKYTKNLI DMARQRKLDP
VIGRDDEIRR VITILSRRTK NNPVLIGDAG VGKTAIIEGI AQRIYKGDVP ESLKDKIVLS
LDLGALIAGA KYRGEFEERL KSVLKEITKG EGKYILFIDE LHTLVGAGAA EGAMDASNML
KPALARGELR SIGATTIKEY RKYIEKDTAL TRRFQPVMVS EPTVEQTITI LRGLKEKYEV
HHGIHIKDSA LIAAATLSSR YITDRFLPDK AIDLIDEASS RLRIELDSIP LEMDEIHRKI
IQLQIEEQAL KRENENEHNN QLNICQDEII RQQKEYETLK EQWEKEKNVI TTISKINEQI
GQTKNDEEKA TREGDLGKAA ELRYGKRLNL QKERERLQKK LKELTKNKKM LRQEVSEENI
AQIVAQWTSI PVTRLLEGEK EKILEMEDRM RERVIGQDQA LNLVSNAIRR ARSGIQDPDR
PIGSFIFLGP TGVGKTETAK ALAEFLFDSE DALIRIDMSE YMEKHSVARL IGAPPGYIGY
DEGGQLTEAV RRAPYSVILF DEIEKAHHDV FNILLQVLDD GRLTDGKGRT IDFRNTILVM
TSNIGGSMIA EHKRNLNEEL ITQIKKMLKS YFLPEFLNRV DDIVIFNFLS KENIEKIVDV
QIRELNHILA TRKVKINLSK SAREKLADIG FDPENGARSL KRAIQRNIQD RLATSLLMGE
IQQDQTLMID IDNSGKFIFK
//
